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首页> 外文期刊>Emerging Infectious Diseases >WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients
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WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients

机译：异基因造血细胞移植受者呼吸样品中的WU和KI多瘤病毒。

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摘要

Data are limited regarding 2 new human polyoma-viruses, KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV), in immunocompromised patients. We used real-time PCR to test for these and 12 respiratory viruses in 2,732 nasal wash samples collected during the fi rst year after allogeneic hematopoietic cell transplantation from 222 patients. Specimens were collected weekly until day 100; then at least every 3 months. One year after hematopoietic cell transplantation, the cumulative incidence estimate was 26% for KIPyV and 8% for WUPyV. Age <20 years predict-ed detection of KIPyV (hazard ratio [HR] 4.6) and WUPyV (HR 4.4), and detection of a respiratory virus in the previ-ous 2 weeks predicted KIPyV detection (HR 3.4). Sputum production and wheezing were associated with detection of KIPyV in the past week and WUPyV in the past month. There were no associations with polyomavirus detection and acute graft versus host disease, cytomegalovirus re-activation, neutropenia, lymphopenia, hospitalization, or death.
机译：关于免疫受损患者中2种新的人类多瘤病毒KI多瘤病毒（KIPyV）和WU多瘤病毒（WUPyV）的数据有限。我们使用实时荧光定量PCR检测了来自222例患者的异基因造血细胞移植后第一年收集的2,732份鼻洗样本中的这些病毒和12种呼吸道病毒。每周收集标本，直到第100天为止。然后至少每3个月一次。造血细胞移植一年后，KIPyV的累积发生率估计为26％，WUPyV的累积发生率为8％。年龄小于20岁的人预测检测到KIPyV（危险比[HR] 4.6）和WUPyV（HR 4.4），并且在之前的两周内检测到呼吸道病毒可预测KIPyV检测（HR 3.4）。痰的产生和喘息与过去一周检测到的KIPyV和过去一个月检测到的WUPyV有关。与多瘤病毒的检测以及急性移植物抗宿主病，巨细胞病毒再激活，中性粒细胞减少，淋巴细胞减少，住院或死亡没有关联。

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