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首页> 外文期刊>Emerging Infectious Diseases >Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998–2012
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Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998–2012

机译：1998-2012年，新西兰沙门氏菌血清型鼠伤寒沙门氏菌DT160与14年暴发相关的基因组分析

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During 1998–2012, an extended outbreak of Salmonella enterica serovar Typhimurium definitive type 160 (DT160) affected 3,000 humans and killed wild birds in New Zealand. However, the relationship between DT160 within these 2 host groups and the origin of the outbreak are unknown. Whole-genome sequencing was used to compare 109 Salmonella Typhimurium DT160 isolates from sources throughout New Zealand. We provide evidence that DT160 was introduced into New Zealand around 1997 and rapidly propagated throughout the country, becoming more genetically diverse over time. The genetic heterogeneity was evenly distributed across multiple predicted functional protein groups, and we found no evidence of host group differentiation between isolates collected from human, poultry, bovid, and wild bird sources, indicating ongoing transmission between these host groups. Our findings demonstrate how a comparative genomic approach can be used to gain insight into outbreaks, disease transmission, and the evolution of a multihost pathogen after a probable point-source introduction.
机译：在1998年至2012年期间，新西兰的沙门氏菌血清型鼠伤寒沙门氏菌最终定型160（DT160）广泛爆发，影响了超过3,000人，并杀死了野生鸟类。但是，这两个宿主组中的DT160与爆发源之间的关系尚不清楚。使用全基因组测序比较了来自新西兰各地的109株鼠伤寒沙门氏菌DT160分离株。我们提供的证据表明，DT160于1997年左右引入新西兰，并迅速在全国范围内传播，随着时间的推移，其遗传多样性也越来越强。遗传异质性均匀地分布在多个预测的功能蛋白组中，我们没有发现从人，家禽，牛和野禽来源分离出的分离株之间存在宿主组差异的证据，表明这些宿主组之间正在进行传播。我们的发现表明，在可能的点源引入之后，如何使用比较基因组方法来深入了解暴发，疾病传播和多宿主病原体的进化。

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