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首页> 外文期刊>Emerging Infectious Diseases >Spectrum of Infection and Risk Factors for Human Monkeypox, United States, 2003
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Spectrum of Infection and Risk Factors for Human Monkeypox, United States, 2003

机译：美国，2003年人类猴痘的感染谱和危险因素

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For the 2003 monkeypox virus (MPXV) outbreak in the United States, interhuman transmission was not docu-mented and all case-patients were near or handled MPXV-infected prairie dogs. We initiated a case–control study to evaluate risk factors for animal-to-human MPXV transmis-sion. Participants completed a questionnaire requesting exposure, clinical, and demographic information. Serum samples were obtained for analysis of immunoglobulin G (IgG) and IgM to orthopoxvirus. When data were adjusted for smallpox vaccination, case-patients were more likely than controls to have had daily exposure to a sick animal (odds ratio [OR] 4.0, 95% confi dence interval [CI] 1.2–13.4), cleaned cages and bedding of a sick animal (OR 5.3, 95% CI 1.4–20.7), or touched a sick animal (OR 4.0, 95% CI 1.2–13.4). These fi ndings demonstrate that human MPXV infection is associated with handling of MPXV-infected ani-mals and suggest that exposure to excretions and secre-tions of infected animals can result in infection
机译：对于2003年在美国爆发的猴痘病毒（MPXV），没有记载人际传播，所有病例患者都靠近或处理了感染MPXV的草原土拨鼠。我们启动了一项病例对照研究，以评估动物向人MPXV传播的危险因素。参与者填写了一份问卷，要求提供暴露，临床和人口统计学信息。获得血清样品以分析针对正痘病毒的免疫球蛋白G（IgG）和IgM。调整天花疫苗接种数据后，病例患者比对照组更可能每天接触患病的动物（赔率[OR] 4.0，95％置信区间[CI] 1.2-13.4），干净的笼子和被褥患病动物（OR 5.3，95％CI 1.4–20.7）或接触过患病动物（OR 4.0，95％CI 1.2-13.4）。这些发现表明，人MPXV感染与MPXV感染的动物的处理有关，并表明暴露于受感染动物的排泄物和分泌物会导致感染。

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