Making Better Influenza Virus Vaccines?

P. Palese

首页> 外文期刊>Emerging Infectious Diseases >Making Better Influenza Virus Vaccines?

【24h】

Making Better Influenza Virus Vaccines?

机译：制作更好的流感病毒疫苗？

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Killed and live influenza virus vaccines are effective inpreventing and curbing the spread of disease, but newtechnologies such as reverse genetics could be used toimprove them and to shorten the lengthy process of prepar-ing vaccine seed viruses. By taking advantage of thesenew technologies, we could develop live vaccines thatwould be safe, cross-protective against variant strains, andrequire less virus per dose than conventional vaccines.Furthermore, pandemic vaccines against highly virulentstrains such as the H5N1 virus can only be generated byreverse genetics techniques. Other technologic break-throughs should result in effective adjuvants for use withkilled and live vaccines, increasing the number of availabledoses. Finally, universal influenza virus vaccines seem tobe within reach. These new strategies will be successful ifthey are supported by regulatory agencies and if a robustmarket for influenza virus vaccines against interpandemicand pandemic threats is made and sustained

机译：死活流感病毒疫苗可以有效地预防和控制疾病的传播，但是可以使用诸如逆向遗传学之类的新技术来改进它们并缩短准备疫苗种子病毒的漫长过程。通过利用这些新技术，我们可以开发出安全，对变异株具有交叉保护作用的活疫苗，并且每剂量所需的病毒量要比传统疫苗少。此外，针对高毒力菌株（例如H5N1病毒）的大流行疫苗只能通过反向遗传来生产技术。其他技术突破应产生有效的佐剂，用于佐剂和活疫苗，增加可用剂量的数量。最后，通用流感病毒疫苗似乎触手可及。如果这些新策略得到监管机构的支持，并且建立并维持了针对大流行间和大流行性威胁的流感病毒疫苗的强大市场，这些新策略将是成功的。

著录项

来源
《Emerging Infectious Diseases》 |2006年第1期|共5页
作者
P. Palese;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类传染病;
关键词

相似文献

外文文献
中文文献
专利

1. Towards a universal vaccine for avian influenza: Protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus [J] . Amy C. Boyd, Raul Ruiz-Hernandez, Marylene Y. Peroval, Vaccine . 2013,第4期

机译：迈向禽流感通用疫苗：经修饰的痘苗病毒安卡拉和腺病毒疫苗在低致病性禽流感病毒攻击的鸡中表达保守流感抗原的保护作用
2. Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1-3 April 2014 [J] . Ampofo William K., Azziz-Baumgartner Eduardo, Bashir Uzma, Vaccine . 2015,第36期

机译：加强流感疫苗病毒的选择和开发过程2014年4月1-3日在瑞士日内瓦世卫组织总部举行的第三次世界卫生组织关于改善流感疫苗病毒选择的非正式磋商会的报告
3. Strengthening the influenza vaccine virus selection and development process Outcome of the 2nd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at the Centre International de Conferences (CICG) Geneva, Switzerland, 7 to 9 December 2011 [J] . Al Busaidy Suleiman, Al-Gohary Amany, Ampofo William K., Vaccine . 2013,第32期

机译：加强流感疫苗病毒的选择和开发过程2011年12月7日至9日在瑞士日内瓦国际会议中心举行的第二次世界卫生组织改善流感疫苗病毒选择的非正式磋商会的成果
4. Vaccine efficacy of live-attenuated virus, whole-virus inactivated and alphavirus vectored subunit vaccines against antigenically distinct H3N2 swine influenza A viruses [C] . Eugenio J. Abente, Nicola S. Lewis, Mark A. Mogler, Annual^Meeting of the American^Association^of^Swine^Veterinarians. . 2016

机译：活病毒的疫苗疗效，全病毒灭活和alphavirus向量亚单位疫苗反对抗原性不同的H3N2猪流感病毒
5. The immune response in horses to vaccination against equine influenza virus. A comparison of recombinant DNA, inactivated-virus, and modified-live virus vaccines. [D] . Sweat, James Mark. 2001

机译：马对马流感病毒疫苗的免疫反应。重组DNA，灭活病毒和改良活病毒疫苗的比较。
6. Towards a universal vaccine for avian influenza: Protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus [O] . Amy C. Boyd, Raul Ruiz-Hernandez, Marylene Y. Peroval, -1

机译：迈向禽流感通用疫苗：经修饰的痘苗病毒安卡拉和腺病毒疫苗在低致病性禽流感病毒攻击的鸡中表达保守流感抗原的保护作用
7. Towards a universal vaccine for avian influenza: Protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus [O] . Boyd, AC, Ruiz-Hernandez, R, Peroval, MY, 2013

机译：迈向禽流感通用疫苗：经修饰的痘苗病毒安卡拉和腺病毒疫苗在低致病性禽流感病毒攻击的鸡中表达保守流感抗原的保护作用
8. Influenza A Virus Aboard a U.S. Navy Ship in 1972 and the Antibody Response of the Crew to Influenza Vaccine. [R] . Green, I. J., Irving, G. S., Hung, S. C., 1974

机译：1972年美国海军舰船上的甲型流感病毒和船员对流感疫苗的抗体反应。

Making Better Influenza Virus Vaccines?

摘要

著录项

相似文献

相关主题

期刊订阅