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Clinical and Radiologic Characteristics of Human Metapneumovirus Infections in Adults, South Korea

机译:成人成人间质肺炎病毒感染的临床和放射学特征

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Clinical features of human metapneumovirus (HMPV) infection have not been well documented for adults. We investigated clinical and radiologic features of HMPV infection in 849 adults in a tertiary hospital in South Korea. We classified patients into groups on the basis of underlying diseases: immunocompetent patients, solid tumor patients, solid organ transplantation recipients, hematopoietic stem cell transplant recipients, hematologic malignancy patients, and patients receiving long-term steroid treatment. Of 849 HMPV-infected patients, 756 had community-acquired infections, 579 had pneumonia, and 203 had infections with other pathogens. Mortality rates were highest in hematopoietic stem cell transplantation recipients (22% at 30 days). Older age, current smoking, and underlying disease were associated with HMPV pneumonia. Body mass index and an immunocompromised state were associated with 30-day mortality rates in HMPV-infected patients. Bronchial wall thickening, ground-glass opacity, and ill-defined centrilobular nodules were common computed tomography findings for HMPV pneumonia. Macronodules and consolidation were observed in 50% of patients.
机译:对于成年人,人类偏肺病毒(HMPV)感染的临床特征尚未得到充分记录。我们在韩国一家三级医院调查了849名成人的HMPV感染的临床和放射学特征。我们根据潜在疾病将患者分为几类:有免疫能力的患者,实体瘤患者,实体器官移植患者,造血干细胞移植患者,血液系统恶性肿瘤患者和接受长期类固醇治疗的患者。在849例HMPV感染患者中,756例是社区获得性感染,579例是肺炎,203例是其他病原体感染。造血干细胞移植接受者的死亡率最高(30天时为22%)。年龄较大,目前吸烟和潜在疾病均与HMPV肺炎有关。体重指数和免疫功能低下状态与HMPV感染患者的30天死亡率相关。支气管壁增厚,毛玻璃样混浊和不明确的小叶结节是HMPV肺炎的常见计算机断层扫描表现。在<50%的患者中观察到巨节和巩固。

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