...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging Infectious Diseases >Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis
【24h】

Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis

机译：结核分枝杆菌的两个完整基因组中同义核苷酸取代的全基因组模式

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Comparison of the pattern of synonymous nucleotide substitu-tion between two complete genomes of Mycobacterium tuber-culosis at 3,298 putatively orthologous loci showed a meanpercent difference per synonymous site of 0.000328 ±0.000022. Although 80.5% of loci showed no synonymous ornonsynonymous nucleotide differences, the level of polymor-phism observed at other loci was greater than suggested byprevious studies of a small number of loci. This level of nucle-otide difference leads to the conservative estimate that thecommon ancestor of these two genotypes occurred approxi-mately 35,000 ago, which is twice as high as some recent esti-mates of the time of origin of this species. Our results suggestthat a large number of loci should be examined for an accurateassessment of the level of nucleotide diversity in natural popu-lations of pathogenic microorganisms
机译：比较结核分枝杆菌的两个完整基因组在3298个推定直系同源位点上的同义核苷酸取代模式的比较，发现每个同义位点的平均差异为0.000328±0.000022。尽管80.5％的基因座未显示同义或非同义的核苷酸差异，但在其他基因座上观察到的多态性水平高于少数基因座的先前研究所表明的水平。这种核苷酸差异的水平导致保守估计，这两个基因型的共同祖先大约发生在35,000年前，是该物种起源时一些最近的估计的两倍。我们的研究结果表明，应检查大量基因座，以准确评估病原微生物自然种群中核苷酸多样性的水平。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号