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首页> 外文期刊>Emerging Infectious Diseases >Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France
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Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France

机译：免疫适应性婴儿和免疫抑制成人中的次生肺孢子虫双氢蝶呤合酶基因型，法国，亚眠

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摘要

To date, investigations of Pneumocystis jirovecii circu-lation in the human reservoir through the dihydropteroatesynthase (DHPS) locus analysis have only been conductedby examining P. jirovecii isolates from immunosuppressedpatients with Pneumocystis pneumonia (PCP). Our studyidentifies P. jirovecii genotypes at this locus in 33 immuno-competent infants colonized with P. jirovecii contemporane-ously with a bronchiolitis episode and in 13 adults withPCP; both groups of patients were monitored in Amiens,France. The results have pointed out identical features of P.jirovecii DHPS genotypes in the two groups, suggestingthat in these groups, transmission cycles of P. jiroveciiinfections are linked. If these two groups represent sentinelpopulations for P. jirovecii infections, our results suggestthat all persons parasitized by P. jirovecii, whatever theirrisk factor for infection and the form of parasitism theyhave, act as interwoven circulation networks of P. jirovecii
机译：迄今为止，通过二氢蝶呤合酶（DHPS）基因座分析对人类贮库中的吉氏肺孢子菌循环进行的研究仅通过检查免疫抑制的肺炎性肺孢子虫（PCP）患者的吉氏罗氏杆菌分离株进行。我们的研究确定了在33个同时患有细支气管炎并伴有细支气管炎发作的免疫能力正常的婴儿中，在该位点有33。两组患者均在法国亚眠进行了监测。结果指出了两组中毕氏疟原虫DHPS基因型的相同特征，这表明在这些组中，毕氏疟原虫感染的传播周期是相关的。如果这两个群体代表了吉氏疟原虫感染的前哨种群，我们的结果表明，所有被吉氏疟原虫寄生的人，无论其感染的危险因素和寄生虫的形式如何，都可以作为吉氏疟原虫交织的循环网络。

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