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Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance

机译:带有erm(B)和mef(A)耐药性的肺炎链球菌的出现和传播

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Streptococcus pneumoniae isolates (N = 31,001) werecollected from patients with community-acquired respirato-ry tract infections during the PROTEKT US surveillancestudy (2000–2003). While the macrolide (erythromycin)resistance rate remained stable at ≈29%, the prevalence ofresistant isolates containing both erm(B) and mef(A)increased from 9.7% in year 1 to 16.4% in year 3, with sub-stantial regional variability. Almost all (99.2%) dualerm(B)+mef(A) macrolide-resistant isolates exhibited mul-tidrug resistance, whereas 98.6% and 99.0% were lev-ofloxacin- and telithromycin-susceptible, respectively.These strains were most commonly isolated from the ear ormiddle-ear fluid of children. Of 152 representativeerm(B)+mef(A) isolates, >90% were clonally related to themultidrug-resistant international Taiwan19F-14 clonal com-plex 271 (CC271). Of 366 erm(B)+mef(A) isolates from thePROTEKT global study (1999–2003), 83.3% were CC271,with the highest prevalence seen in South Africa, SouthKorea, and the United States. This study confirms theincreasing global emergence and rapidly increasing USprevalence of this multidrug-resistant pneumococcal clone
机译:在美国PROTEKT监测研究(2000-2003年)期间,从社区获得性呼吸道感染患者中收集肺炎链球菌分离株(N = 31,001)。虽然大环内酯类药物(红霉素)的耐药率稳定在≈29%,但同时含有erm(B)和mef(A)的耐药菌株的流行率从第1年的9.7%增加到第3年的16.4%,区域差异很大。几乎所有(99.2%)对Dualerm(B)+ mef(A)的大环内酯类耐药菌株均表现出多药耐药性,而对左氧氟沙星和替利霉素的敏感性分别为98.6%和99.0%。儿童的耳朵或中耳液体。在152个代表性(B)+ mef(A)分离株中,> 90%与耐多药的国际台湾19F-14克隆复合物271(CC271)克隆相关。在全球PROTEKT研究(1999-2003年)的366 erm(B)+ mef(A)分离株中,CC271为83.3%,在南非,韩国和美国的患病率最高。这项研究证实了这种具有多重耐药性的肺炎球菌克隆在全球范围内的流行和在美国的流行迅速增加

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