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Human Disease from Influenza A (H5N1), Thailand, 2004

机译:泰国,2004年,甲型H5N1流感引起的人类疾病

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Influenza A (H5N1) is endemic in poultry across muchof Southeast Asia, but limited information exists on the dis-tinctive features of the few human cases. In Thailand, weinstituted nationwide surveillance and tested respiratoryspecimens by polymerase chain reaction and viral isola-tion. From January 1 to March 31, 2004, we reviewed 610reports and identified 12 confirmed and 21 suspectedcases. All 12 confirmed case-patients resided in villagesthat experienced abnormal chicken deaths, 9 lived inhouseholds whose backyard chickens died, and 8 reporteddirect contact with dead chickens. Seven were children <14years of age. Fever preceded dyspnea by a median of 5days, and lymphopenia significantly predicted acute respi-ratory distress syndrome development and death. Amonghundreds of thousands of potential human cases of influen-za A (H5N1) in Asia, a history of direct contact with sickpoultry, young age, pneumonia and lymphopenia, and pro-gression to acute respiratory distress syndrome shouldprompt specific laboratory testing for H5 influenza
机译:甲型H5N1流感在东南亚大部分地区的家禽中很流行,但是关于少数人类病例的独特特征的信息有限。在泰国,我们发起了全国性的监测,并通过聚合酶链反应和病毒分离对呼吸道标本进行了测试。从2004年1月1日至3月31日,我们审查了610份报告,确定了12例确诊病例和21例可疑病例。所有12名确诊病例患者均居住在鸡异常死亡的村庄中,有9户家庭住户的后院鸡死亡,还有8例直接与死鸡接触。 7名是14岁以下的儿童。发烧在呼吸困难之前中位数为5天,而淋巴细胞减少明显预测了急性呼吸窘迫综合征的发生和死亡。在亚洲成千上万的潜在人类流行性感冒A(H5N1)病例中,有直接接触病禽,年轻人,肺炎和淋巴细胞减少的病史,以及急性呼吸窘迫综合征的进展,应促使对H5流感进行专门的实验室检测

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