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Leprosy as Immune Reconstitution Inflammatory Syndrome in HIV-positive Persons

机译:麻风病作为艾滋病毒阳性患者的免疫重建炎症综合症

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To the Editor: More than 2 de-cades ago, when HIV was fi rst de-tected, many investigators predicted the rise of leprosy secondary to op-portunistic infection (1). Recently, the phenomenon of immune reconstitu-tion in. ammatory syndrome (IRIS), or leprosy reversal response, has re-ceived attention. IRIS often occurs secondary to initiating highly active antiretroviral therapy (HAART). The fi rst indications of an interaction be-tween HIV and Mycobacterium leprae occurred only recently, with the iden-tifi cation of IRIS after initiation of HAART in patients with HIV and pre-viously undetected leprosy. A review by Pustianowski et al. discusses the paradox of HIV and leprosy with IRIS (2). In addition, Lawn et al. described the fi rst case of IRIS after the onset of HAART in a patient who had tubercu-loid leprosy that was never confi rmed by molecular analysis (3).
机译:致编辑:超过两个十年前,当首次检测到艾滋病毒时,许多研究人员预测,机会性感染继发的麻风病会增加(1)。近年来,免疫综合征(IRIS)中的免疫重建现象或麻风逆转反应受到了关注。 IRIS通常在高活性抗逆转录病毒疗法(HAART)启动后发生。 HIV和麻风分枝杆菌之间相互作用的第一个迹象仅在最近才发生,在HIV患者和以前未被发现的麻风病患者中,开始进行HAART后IRIS的鉴定。 Pustianowski等人的评论。与IRIS讨论了HIV和麻风病的悖论(2)。此外,草坪等。他描述了HAART发病后IRIS的第一例病例,该患者患有结核样麻风病,但从未通过分子分析证实(3)。

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