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首页> 外文期刊>Emerging Infectious Diseases >Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France
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Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France

机译：法国巴黎，血液培养的耐氟胞嘧啶热带假丝酵母的克隆种群

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Candida tropicalis is a diploid ascomycetes yeast re-sponsible for 4%–24% of candidemia. Resistance to . ucy-tosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the . ucyto-sine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and ge-nomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of . ucytosine-resistant isolates, asso-ciated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone
机译：热带念珠菌是一种二倍体子囊菌酵母菌，占念珠菌血症的4％–24％。抵抗。尿嘧啶很少被描述用于该物种，但在为期4年的调查中，从巴黎的血液培养物中回收到的130株热带弯杆菌中有45株（35％）被观察到。这项研究的目的是为了检验假设。耐胞嘧啶的分离株可能代表一个亚组，并确定流行病学和基因组数据之间的关系。分析流行病学数据和基因序列，并进行分子分型。我们的结果表明存在一个克隆。耐尿嘧啶分离株与恶性肿瘤相关，其死亡率低于其他热带梭状芽胞杆菌分离株，在巴黎地区很普遍。我们建议分析2多态性微卫星标记结合URA3测序以跟踪克隆

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