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Beijing/W Mycobacterium tuberculosis in Italy

机译:意大利北京/ W结核分枝杆菌

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To the Editor: Molecular typingof Mycobacterium tuberculosis strainsisolated in several countries in recentyears has shown that a group ofstrains known as "Beijing" iswidespread around the world (1). TheBeijing group of M. tuberculosis hasbeen associated with drug resistance;one multidrug-resistant strain,designated "W," was found in NewYork City in the early 1990s andcaused large institutional outbreaks oftuberculosis (TB) in the United States(2). M. tuberculosis strains ofBeijing/W genotype are mostlyprevalent in Asia (1), but recent datasuggest that they have been spreadingin Indochina and are prevalent amongyounger persons in Vietnam (3).Beijing/W strains are also widespreadin Eastern Europe (1); during the lastdecade, the Beijing/W genotype of M.tuberculosis, with more prevalentdrug-resistant mutations than non-Beijing strains, has been identified in40% to 50% of clinical isolatesstudied in Russia (4).
机译:致编者:近年来在几个国家分离的结核分枝杆菌菌株的分子分型显示,一组被称为“北京”的菌株在世界范围内广泛传播(1)。北京的结核分枝杆菌群与耐药性有关; 1990年代初在纽约市发现了一种名为“ W”的多药耐药株,在美国引起了大规模的机构性结核病暴发(2)。北京/ W基因型的结核分枝杆菌菌株在亚洲最普遍(1),但最近的数据表明它们已经在印度支那传播,在越南的年轻人中也很普遍(3)。北京/ W菌株在东欧也很普遍(1);在上个十年中,在俄罗斯研究的临床分离株中有40%到50%鉴定出结核分枝杆菌的北京/ W基因型比非北京菌株更具普遍的耐药性(4)。

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