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首页> 外文期刊>Emerging Infectious Diseases >Wild Boars as Hosts of Human-Pathogenic Anaplasma phagocytophilum Variants
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Wild Boars as Hosts of Human-Pathogenic Anaplasma phagocytophilum Variants

机译：野猪作为人类致病性无花果浆变种的宿主

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To the Editor: Michalik et al. (1) reported a 12% prevalence of Ana-plasma phagocytophilum, the caus-ative agent of human granulocytic anaplasmosis and tick-borne fever of ruminants, in wild boars in Poland. A. phagocytophilum has been reported with low prevalence among wild boar in the Czech Republic, Slovenia (2), and Japan (3). In Spain and Missis-sippi, United States, A. phagocyto-philum in wild boars or feral pigs, re-spectively, has not been reported (4,5). Furthermore, in Slovenia and Poland, the A. phagocytophilum gene sequenc-es found in samples from wild boars were identical to those found in sam-ples from humans and the tick vector Ixodes ricinus (1). These results sug-gested, as pointed out by Michalik et al. (1), that wild boar might play a role in the epizootiology of A. phagocyto-philum by serving as a natural reser-voir host, at least in some regions.To test this hypothesis, we con-ducted transcriptomics studies to char-acterize host response to A. phagocy-tophilum infection in naturally and experimentally infected boars (6,7). The results suggested that boars are susceptible to A. phagocytophilum, but are able to control infection, mainly through activation of innate immune responses and cytoskeleton rearrangement to promote phagocy-tosis and autophagy. Control of A. phagocytophilum infection in boars might result in infection levels below PCR detection or infection clearance, contributing to the low percentage of infection prevalence detected for this species in most regions
机译：致编辑：Michalik等。 （1）报告说，在波兰的野猪中，吞噬性Ana-plasma phagocytophilum（人类粒细胞无性病和反刍动物tick传热的病原体）的流行率为12％。据报道，在捷克共和国，斯洛文尼亚（2个）和日本（3个）中，野猪中的嗜A.phagocytophilum患病率较低。在西班牙和美国的Missis-sippi，尚未报告过野猪或野猪中的A.噬菌体（4,5）。此外，在斯洛文尼亚和波兰，从野猪样本中发现的嗜A.phagocytophilum基因序列与从人类和壁虱媒介x虱（Ixodes ricinus）的样本中发现的噬菌体基因序列相同（1）。正如Michalik等人指出的，这些结果被建议。 （1），至少在某些地区，野猪可能通过充当天然的储库宿主在嗜血曲霉的流行病学中发挥作用。为了验证这一假设，我们将转录组学研究应用于在自然和实验感染的公猪中激活宿主对吞噬嗜酸曲霉感染的反应（6,7）。结果表明，公猪对吞噬嗜血曲霉敏感，但能够控制感染，主要通过激活先天免疫应答和细胞骨架重排来促进吞噬-吞噬和自噬。控制公猪吞噬嗜血曲霉的感染可能会导致感染水平低于PCR检测或感染清除率，这导致在大多数地区检测到该物种的感染率较低

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