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首页> 外文期刊>Emerging Infectious Diseases >Serious Invasive Saffold Virus Infections in Children, 2009
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Serious Invasive Saffold Virus Infections in Children, 2009

机译：2009年儿童严重侵袭性支架病毒感染

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The fi rst human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal . uid (CSF) samples from children <4 years of age. SAFV was detected in 2 children: in the CSF and a fecal sample from 1 child with monosymptomatic ataxia caused by cerebellitis; and in the CSF, blood, and myocardium of another child who died suddenly with no history of illness. Virus from each child was sequenced and shown to be SAFV type 2. These fi ndings demonstrate that SAFV can cause serious invasive infection in children
机译：心脏病毒属中的第一种人类病毒已于2007年描述，并命名为Saffold病毒（SAFV）。心脏病毒可引起动物心肌和中枢神经系统的严重感染，但SAFV尚未令人信服地与人类疾病相关。为了研究SAFV与人类中枢神经系统感染之间的可能联系，我们设计了SAFV实时PCR并测试了脑脊髓。小于4岁儿童的uid（CSF）样本。在2例儿童中检测到SAFV：在CSF和1例因小脑炎引起的单症状共济失调的儿童的粪便样本中;在脑脊液中，另一个孩子突然死亡而无病史的血液和心肌。对每个孩子的病毒进行了测序，结果显示它们是2型SAFV。这些发现表明SAFV可以导致儿童严重的侵袭性感染。

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