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Aseptic Meningitis Epidemic during a West Nile Virus Avian Epizootic

机译:西尼罗河病毒禽流感流行期间的无菌性脑膜炎流行

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While enteroviruses have been the most commonlyidentified cause of aseptic meningitis in the United States,the role of the emerging, neurotropic West Nile virus (WNV)is not clear. In summer 2001, an aseptic meningitis epidem-ic occurring in an area of a WNV epizootic in Baltimore,Maryland, was investigated to determine the relative contri-butions of WNV and enteroviruses. A total of 113 asepticmeningitis cases with onsets from June 1 to September 30,2001, were identified at six hospitals. WNV immunoglobu-lin M tests were negative for 69 patients with availablespecimens; however, 43 (61%) of 70 patients testedenterovirus-positive by viral culture or polymerase chainreaction. Most (76%) of the serotyped enteroviruses wereechoviruses 13 and 18. Enteroviruses, including previouslyrarely detected echoviruses, likely caused most asepticmeningitis cases in this epidemic. No WNV meningitiscases were identified. Even in areas of WNV epizootics,enteroviruses continue to be important causative agents ofaseptic meningitis
机译:尽管在美国,肠病毒是最常见的无菌性脑膜炎病因,但尚不清楚新兴的神经性西尼罗河病毒(WNV)的作用。 2001年夏季,调查了在马里兰州巴尔的摩市WNV流行区发生的无菌性脑膜炎流行病,以确定WNV和肠病毒的相对贡献。 2001年6月1日至2001年9月30日,共确诊113例无菌性脑膜炎病例,共6家医院。 WNV免疫球蛋白M检验对69例有标本的患者阴性;然而,在70名患者中,有43名(61%)通过病毒培养或聚合酶链反应检测到肠病毒阳性。血清型肠病毒中的大多数(76%)是回肠病毒13和18。肠病毒,包括以前很少检测到的回声病毒,很可能在该流行病中引起了大多数无菌性脑膜炎病例。未发现WNV脑膜炎病例。即使在WNV流行病地区,肠病毒仍是无菌性脑膜炎的重要病原体

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