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首页> 外文期刊>Emerging Infectious Diseases >Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005
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Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

机译：越南南部手足口病的流行病学和病毒学调查，2005年

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摘要

During 2005, 764 children were brought to a large chil-dren's hospital in Ho Chi Minh City, Vietnam, with a diagno-sis of hand, foot, and mouth disease. All enrolled childrenhad specimens (vesicle . uid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identifi ed as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identifi ed HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was iso-lated throughout the year, with a period of higher prevalence in October–November. Phylogenetic analysis of 23 HEV71 isolates showed that during the fi rst half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity
机译：在2005年，有764名儿童被带到越南胡志明市的一家大型儿童医院，对手足口病进行了诊断。收集所有入选儿童的标本（囊泡，uid，粪便，咽喉拭子），以通过细胞培养分离肠病毒。从411（53.8％）个标本中分离出了肠道病毒：173株（42.1％）被鉴定为人肠道病毒71（HEV71），214株（52.1％）被鉴定为柯萨奇病毒A16。在已确定的HEV71感染中，有51例（29.5％）并发急性神经系统疾病，其中3例（1.7％）致命。 HEV71全年处于隔离状态，10月至11月的患病率较高。对23个HEV71分离株的系统发育分析表明，在2005年上半年，越南南部共同传播了属于3个亚基因组C1，C4和一个先前未描述的亚基因组C5的病毒。在下半年，在HEV71活性较高的时期，属于C5亚基因组的病毒占主导地位

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