• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging Infectious Diseases >Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1
【24h】

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

机译：基质蛋白2疫苗接种和针对H5N1亚型的流感病毒的防护

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Changes in influenza viruses require regular reformu-lation of strain-specific influenza vaccines. Vaccines basedon conserved antigens provide broader protection.Influenza matrix protein 2 (M2) is highly conserved acrossinfluenza A subtypes. To evaluate its efficacy as a vaccinecandidate, we vaccinated mice with M2 peptide of a widelyshared consensus sequence. This vaccination inducedantibodies that cross-reacted with divergent M2 peptidefrom an H5N1 subtype. A DNA vaccine expressing full-length consensus-sequence M2 (M2-DNA) induced M2-specific antibody responses and protected againstchallenge with lethal influenza. Mice primed with M2-DNAand then boosted with recombinant adenovirus expressingM2 (M2-Ad) had enhanced antibody responses that cross-reacted with human and avian M2 sequences and pro-duced T-cell responses. This M2 prime-boost vaccinationconferred broad protection against challenge with lethalinfluenza A, including an H5N1 strain. Vaccination with M2,with key sequences represented, may provide broad pro-tection against influenza A
机译：流感病毒的变化需要定期重新配置菌株特异性流感疫苗。基于保守抗原的疫苗提供了更广泛的保护。流感基质蛋白2（M2）在A型流感亚型中是高度保守的。为了评估其作为候选疫苗的功效，我们给小鼠接种了广泛共有的共有序列的M2肽。该疫苗诱导了与来自H5N1亚型的不同M2肽交叉反应的抗体。表达全长共有序列M2（M2-DNA）的DNA疫苗可诱导M2特异性抗体反应，并具有抵抗致命流感的攻击能力。用M2-DNA引发的小鼠，然后用表达M2的重组腺病毒（M2-Ad）加强，小鼠的抗体应答增强，与人和禽类M2序列交叉反应，并产生T细胞应答。这种M2初免-加强疫苗接种可对包括H5N1株在内的致死性甲型流感病毒提供广泛的保护。带有关键序列的M2疫苗接种可提供广泛的A型流感防护

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号