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Worldwide Emergence of Extensively Drug-resistant Tuberculosis

机译:全球广泛耐药结核的出现

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Mycobacterium tuberculosis strains that are resistantto an increasing number of second-line drugs used to treatmultidrug-resistant tuberculosis (MDR TB) are becoming athreat to public health worldwide. We surveyed the Networkof Supranational Reference Laboratories for M. tuberculo-sis isolates that were resistant to second-line anti-TB drugsduring 2000–2004. We defined extensively drug-resistantTB (XDR TB) as MDR TB with further resistance to >3 ofthe 6 classes of second-line drugs. Of 23 eligible laborato-ries, 14 (61%) contributed data on 17,690 isolates, whichreflected drug susceptibility results from 48 countries. Of3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria forXDR TB. Further investigation of population-based trendsand expanded efforts to prevent drug resistance and effec-tively treat patients with MDR TB are crucial for protectionof public health and control of TB
机译:对越来越多的用于治疗耐多药结核病(MDR TB)的二线药物具有耐药性的结核分枝杆菌菌株正威胁着全世界的公共卫生。我们调查了超国家参考实验室网络的结核分枝杆菌分离株,这些分离株在2000–2004年期间对二线抗结核药物具有耐药性。我们将广泛耐药的结核病(XDR TB)定义为耐多药结核病,对6类二线药物的耐药性进一步> 3。在23个符合条件的实验室中,有14个(61%)提供了有关17690株分离株的数据,反映了48个国家的药物敏感性结果。在3,520(19.9%)耐多药结核病分离株中,有347(9.9%)符合XDR TB标准。进一步调查基于人群的趋势并加大力度预防耐药和有效治疗耐多药结核病对于保护公共卫生和控制结核病至关重要

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