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Novel Nonstructural Protein 4 Genetic Group in Rotavirus of Porcine Origin

机译:猪源轮状病毒中的新型非结构蛋白4基因组。

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To the Editor: Infection with group A rotavirus is the main cause of acute gastroenteritis in infants and young children worldwide and in young animals of many species, in-cluding piglets. In recent years, sev-eral epidemiologic studies designed to monitor the appearance of novel or atypical rotavirus antigenic types have provided evidence for the in-creasing antigenic diversity of group A rotaviruses (1–3). In addition to the 2 rotavirus classifi cation systems, VP7 (G) and VP4 (P) genes, the virus can also be classifi ed on the basis of the nonstructural glycoprotein 4 (NSP4)–encoding gene. Sequence analyses of the NSP4 gene indicated the presence of at least 5 distinct genetic groups among human and animal rotaviruses, termed A to E (1,4,5). Among human rotaviruses, the diversity of NSP4 genes has been restricted mainly to genetic groups A and B; only a few human strains possess genetic group C. Conversely, all 5 NSP4 genetic groups (A–E) have been identifi ed in rotaviruses of animal origins. To our knowledge, porcine rotaviruses (PoR-Vs) have been reported to belong only to NSP4 genetic group B (1).
机译:致编者:轮状病毒A型感染是全世界婴幼儿以及包括猪仔在内的许多物种的幼小动物急性肠胃炎的主要原因。近年来,旨在监测新型或非典型轮状病毒抗原类型出现的几项流行病学研究为甲组轮状病毒的抗原多样性不断增加提供了证据(1-3)。除了2个轮状病毒分类系统VP7(G)和VP4(P)基因之外,还可以根据非结构糖蛋白4(NSP4)编码基因对病毒进行分类。 NSP4基因的序列分析表明,在人和动物轮状病毒中存在至少5个不同的遗传基团,称为A到E(1、4、5)。在人类轮状病毒中,NSP4基因的多样性主要限于基因A和B。只有少数几株具有C基因组。相反,所有5个NSP4基因组(A–E)在动物源轮状病毒中均已鉴定。据我们所知,猪轮状病毒(PoR-Vs)据报道仅属于NSP4基因B组(1)。

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