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首页> 外文期刊>Emerging Infectious Diseases >Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia
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Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia

机译：俄罗斯多布拉瓦汉坦病毒的2个谱系引起的肾综合征出血热

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摘要

Dobrava-Belgrade virus (DOBV) is a European hanta-virus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were iso-lated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clini-cal severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe
机译：多布拉瓦-贝尔格莱德病毒（DOBV）是一种欧洲汉坦病毒，可引起肾综合征出血热（HFRS）;巴尔干国家的病死率高达12％。为了确定病因，我们在俄罗斯中部和南部俄罗斯检查了126例与DOBV相关的HFRS。在俄罗斯中部（利佩茨克，沃罗涅日，奥勒尔地区），暴发是由黑线姬鼠携带的DOBV变种（DOBV-Aa）引起的。在HFRS流行的俄罗斯南部地区（索契地区），HFRS病例是由新型汉坦病毒自然宿主A. ponticus中发现的一种新的DOBV变异体（DOBV-Ap）引起的。两种病毒，即DOBV-Aa / Lipetsk和DOBV-Ap / Sochi，都是通过Vero E6细胞分离的，具有遗传特征，并用于HFRS患者血清的血清分型。 DOBV-Aa引起的HFRS的临床严重程度与Puumala病毒引起的HFRS的临床严重程度相似（轻度至中度）。由DOBV-Ap感染引起的疾病的临床严重程度通常为中度至重度

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