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首页> 外文期刊>Emerging Infectious Diseases >Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza
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Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

机译：近期已接种流感疫苗的人群中针对禽流感的跨亚型免疫

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Avian in. uenza virus (H5N1) can be transmitted to hu-mans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian in. uenza (H5N1) strains in healthy donors vaccinated for seasonal in. uenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specifi c for subtype H5N1 was de-tected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against in. uenza (H5N1) in a large number of donors. No correlation between in. uenza-specifi c CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These fi ndings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian in. uenza A virus subtype H5N1 by seasonal in. uenza vaccination
机译：禽流感病毒（H5N1）可以传播给人类，导致严重或致命的疾病。这项研究的目的是评估在针对季节性流感A（H1N1）/（H3N2）进行了疫苗接种的健康供体中，人与禽流感（H5N1）株之间的免疫交叉反应。在基线时，在几个人中检测到了针对H5N1亚型的少量CD4 T细胞，并且季节性接种疫苗增加了这种反应性CD4 T细胞的频率。我们还观察到，季节性疫苗接种能够在许多捐赠者中提高针对流感病毒（H5N1）的中和免疫力。未观察到流感特异性CD4 T细胞与体液反应之间的相关性。 N1可能是细胞和体液交叉型免疫的靶标，但需要其他实验来阐明这一点。这些发现突出表明了通过季节性流感疫苗接种来增强针对高致病性禽流感A5亚型H5N1亚型的交叉型细胞和体液免疫的可能性。

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