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首页> 外文期刊>Emerging Infectious Diseases >Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008
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Intestinal Toxemia Botulism in 3 Adults, Ontario, Canada, 2006–2008

机译：2006–2008年，加拿大安大略省，三名成人肠毒性肉毒杆菌中毒

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Five cases of intestinal toxemia botulism in adults were identifi ed within an 18-month period in or near Toronto, Ontario, Canada. We describe fi ndings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41–61 days), indicative of intestinal toxemia botulism. Patients' clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient's feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-fi eld gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism
机译：在加拿大安大略省多伦多市或附近地区，在18个月内确定了5例成年人肠道毒素肉毒中毒病例。我们描述了5名病例患者中3名的发现。临床样品中含有较长时间（范围为41-61天）的肉毒梭菌孢子和肉毒杆菌神经毒素（A型和B型），表明肠毒物肉毒杆菌中毒。通过支持治疗和肉毒杆菌毒素的给予，患者的临床症状得到改善。一名案例患者住所的花生酱产生了A型肉毒梭菌，与患者粪便中发现的A型孢子相对应。该病例患者的食品和临床分离株无法通过脉冲场凝胶电泳进行区分。其中两名病例患者患有克罗恩病，并曾接受过大肠手术，这可能是导致肉毒梭菌感染的原因。这些案例强化了以下观点：潜在的胃肠道疾病是成人肠道毒血症肉毒中毒的危险因素

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