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首页> 外文期刊>Emerging Infectious Diseases >Detection of Pandemic (H1N1) 2009 Virus in Patients Treated with Oseltamivir
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Detection of Pandemic (H1N1) 2009 Virus in Patients Treated with Oseltamivir

机译：Oseltamivir治疗的患者中2009大流行（H1N1）病毒的检测

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To the Editor: In April 2009, an in. uenza outbreak caused by a novel strain of in. uenza virus A (H1N1) was identifi ed in Mexico. The rapid spread of this new virus among humans led the World Health Organization to raise the phase of pandemic alert to 6. We report results from the 2 virology laboratories from university hospitals that were in-volved in the surveillance network of pandemic (H1N1) 2009 in Paris at the beginning of the outbreak in France.Patients exhibiting in. uenza-like illness (i.e., fever, sore throat, cough, asthenia, headache, myalgia) and who recently had traveled to countries where the pandemic (H1N1) 2009 outbreak had started (i.e., Mexico, United States, Canada, Japan) were hospitalized. Symptoms began either the day before or the day of hospital-ization. Nasal-swab specimens were collected at admission by using the Virocult system (ELITech; Salon-de-Provence, France), and treatment with oseltamivir was started (75 mg, 2×/day). Pandemic (H1N1) 2009 in-fection was diagnosed by using rapid test QuickVue In. uenza A+B (Quidel, San Diego, CA, USA) and real-time reverse transcription–PCR (RT-PCR) assays from the French National In-. uenza Centers or the US Centers for Disease Control and Prevention (1). In the case of a positive result, in. uenza virus in nasal secretions from patients was monitored daily by RT-PCR until viral genomes became undetectable.From April 24 through June 7, 2009, nasal swab specimens from 234 persons (132 men; median age of all patients 33 years) were pro-cessed; pandemic (H1N1) 2009 infec-tion was confi rmed for 17 men and 15 women (median age 33 years) by RT-PCR. Results of the Quidel rapid tests were available for 27 specimens, with positive results for 9 (33% sen-sitivity). However, no positive result was observed with the Quidel rapid tests among the nasal swab specimens with negative RT-PCR results (100% specifi city). In. uenza virus detection in nasal secretions was monitored for 16 patients who had laboratory-con-fi rmed pandemic (H1N1) 2009 infec-tion and were treated with oseltamivir. Viral detection by RT-PCR was absent 2 to >5 days after antiviral treatment began (Figure). Signifi cant differences were not found in sex and age of the patients (data not shown).
机译：致编辑：2009年4月，在墨西哥发现了由新型流感病毒A（H1N1）株引起的流感大爆发。这种新病毒在人类中的迅速传播，导致世界卫生组织将大流行警报的阶段提高到6个。我们报告了参与2009年H1N1大流行监测网络的大学医院的2个病毒学实验室的结果在法国爆发暴发开始时在巴黎。患者出现类似uenza的疾病（例如发烧，喉咙痛，咳嗽，乏力，头痛，肌痛），并且最近曾去过2009年H1N1大流行的国家已经开始（即墨西哥，美国，加拿大，日本）住院。症状开始于住院的前一天或当天。入院时使用Virocult系统（ELITech; Salon-de-Provence，法国）收集鼻拭子标本，并开始用奥司他韦治疗（75 mg，2x /天）。使用快速测试QuickVue In诊断出2009年H1N1大流行。 uenza A + B（美国加利福尼亚州圣地亚哥的奎德尔市）和来自法国国家情报局的实时逆转录PCR（RT-PCR）测定。 uenza中心或美国疾病控制与预防中心（1）。如果结果呈阳性，则每天通过RT-PCR监测患者鼻分泌物中的流感病毒，直到无法检测到病毒基因组。从2009年4月24日至6月7日，从234人（132名男性;中位数）中收集了鼻拭子样本所有患者的年龄均为33岁）;通过RT-PCR确认2009年甲型H1N1流感大流行有17名男性和15名女性（中位年龄33岁）。 Quidel快速测试的结果可用于27个样本，其中9个（敏感性为33％）为阳性。但是，在RT-PCR结果为阴性（100％指定城市）的鼻拭子样本中，使用Quidel快速测试未观察到阳性结果。在。监测了16名2009年确诊的大流行性流感（H1N1）感染并接受奥司他韦治疗的患者的鼻分泌物中的uenza病毒检测。在开始抗病毒治疗后2至> 5天，没有通过RT-PCR进行病毒检测（图）。在患者的性别和年龄方面未发现明显差异（数据未显示）。

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