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首页> 外文期刊>Emerging Infectious Diseases >Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi from Patients with Scrub Typhus in 3 Regions of India (http://wwwnc.cdc.gov/eid/article/21/1/14-0580)
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Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi from Patients with Scrub Typhus in 3 Regions of India (http://wwwnc.cdc.gov/eid/article/21/1/14-0580)

机译：印度3个地区斑疹伤寒患者东方虫的分子流行病学和遗传多样性（http://wwwnc.cdc.gov/eid/article/21/1/14-0580）

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摘要

Scrub typhus, an acute febrile illness that is widespread in the Asia-Pacific region, is caused by the bacterium Orientia tsutsugamushi , which displays high levels of antigenic variation. We conducted an investigation to identify the circulating genotypes of O. tsutsugamushi in 3 scrub typhus–endemic geographic regions of India: South India, Northern India, and Northeast India. Eschar samples collected during September 2010–August 2012 from patients with scrub typhus were subjected to 56-kDa type-specific PCR and sequencing to identify their genotypes. Kato-like strains predominated (61.5%), especially in the South and Northeast, followed by Karp-like strains (27.7%) and Gilliam and Ikeda strains (2.3% each). Neimeng-65 genotype strains were also observed in the Northeast. Clarifying the genotypic diversity of O. tsutsugamushi in India enhances knowledge of the regional diversity among circulating strains and provides potential resources for future region-specific diagnostic studies and vaccine development.
机译：斑疹伤寒是一种严重的发热性疾病，在亚太地区广泛存在，是由Or虫东方ient菌引起的，该菌表现出高水平的抗原变异性。我们进行了一项调查，以鉴定印度3种灌木斑疹伤寒流行地区（南部印度，印度北部和印度东北部）的tsu虫O.tsutsugamushi的循环基因型。对2010年9月至2012年8月从斑疹伤寒患者身上收集的Eschar样品进行56 kDa类型特异性PCR和测序，以鉴定其基因型。加藤样菌株占主要地位（61.5％），尤其是在南部和东北部，其次是卡普样菌株（27.7％）以及吉列姆和池田菌株（各占2.3％）。在东北也观察到内蒙65基因型菌株。澄清印度tsu虫O.tsutsugamushi的基因型多样性，可增强对循环菌株之间区域多样性的了解，并为将来的特定区域诊断研究和疫苗开发提供潜在资源。

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