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首页> 外文期刊>Emerging Infectious Diseases >Naturally Acquired Antibodies against Haemophilus influenzae Type a in Aboriginal Adults, Canada (http://wwwnc.cdc.gov/eid/article/21/2/14-0722)
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Naturally Acquired Antibodies against Haemophilus influenzae Type a in Aboriginal Adults, Canada (http://wwwnc.cdc.gov/eid/article/21/2/14-0722)

机译：加拿大原住民成年人的A型流感嗜血杆菌天然获得的抗体（http://wwwnc.cdc.gov/eid/article/21/2/14-0722）

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摘要

In the post- Haemophilus influenzae type b (Hib) vaccine era that began in the 1980's, H. influenzae type a (Hia) emerged as a prominent cause of invasive disease in North American Aboriginal populations. To test whether a lack of naturally acquired antibodies may underlie increased rates of invasive Hia disease, we compared serum bactericidal activity against Hia and Hib and IgG and IgM against capsular polysaccharide between Canadian Aboriginal and non-Aboriginal healthy and immunocompromised adults. Both healthy and immunocompromised Aboriginal adults exhibited significantly higher bactericidal antibody titers against Hia than did non-Aboriginal adults (p = 0.042 and 0.045 respectively), with no difference in functional antibody activity against Hib. IgM concentrations against Hia were higher than IgG in most study groups; the inverse was true for antibody concentrations against Hib. Our results indicate that Aboriginal adults possess substantial serum bactericidal activity against Hia that is mostly due to IgM antibodies. The presence of sustained IgM against Hia suggests recent Hia exposure.
机译：在1980年代开始的流感嗜血杆菌B型（Hib）疫苗时代之后，流感嗜血杆菌A型（Hia）成为北美原住民人群侵袭性疾病的重要原因。为了测试缺乏天然获得的抗体是否可能是侵袭性Hia发病率上升的基础，我们比较了加拿大原住民和非原住民健康和免疫功能低下的成年人对Hia和Hib的血清杀菌活性以及针对荚膜多糖的IgG和IgM的杀菌活性。健康和免疫受损的原住民成年人对Hia的杀菌抗体效价均显着高于非原住民成年人（分别为p = 0.042和0.045），而针对Hib的功能抗体活性无差异。在大多数研究组中，针对Hia的IgM浓度高于IgG。对于Hib的抗体浓度则相反。我们的结果表明，原住民成年人具有针对Hia的大量血清杀菌活性，这主要归因于IgM抗体。持续存在的针对Hia的IgM提示最近有Hia暴露。

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