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首页> 外文期刊>Emerging Infectious Diseases >Stability of Middle East Respiratory Syndrome Coronavirus in Milk (http://wwwnc.cdc.gov/eid/article/20/7/14-0500)
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Stability of Middle East Respiratory Syndrome Coronavirus in Milk (http://wwwnc.cdc.gov/eid/article/20/7/14-0500)

机译：牛奶中中东呼吸综合征冠状病毒的稳定性（http://wwwnc.cdc.gov/eid/article/20/7/14-0500）

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To the Editor: Middle East respiratory syndrome coronavirus (MERS-CoV) was first diagnosed in humans in 2012. Human-to-human transmission of MERS-CoV has been limited, and the transmission route is still unclear. On the basis of epidemiologic studies, involvement of an animal host has been suggested (1). Dromedary camels have been identified as a possible intermediate host on the basis of MERS-CoV antibodies and detection of MERS-CoV viral RNA in respiratory swab samples (1– 3). Furthermore, MERS-CoV genome sequences obtained from dromedary camels clustered with MERS-CoV sequences obtained from humans linked to the same farm (2). Nonetheless, most persons with MERS-CoV did not report any direct contact with dromedary camels; therefore, how MERS-CoV zoonotic transmission occurs is unclear. MERS-CoV replicates in cell lines originating from a wide variety of different hosts, which suggests the potential for a broader reservoir species range then currently recognized (4). However, unlike in dromedary camels, no serologic evidence pointing toward MERSCoV infection has been found in goats, sheep, and cows (1). Contamination of dairy products has been associated with transmission of bacteria and viruses. Shedding of infectious tick-borne encephalitis virus in milk was detected after experimental infection of goats, and the consumption of raw milk has been associated with tick-borne encephalitis virus clusters (5). Similarly, cattle can be infected with foot-and-mouth disease through consumption of raw contaminated milk (6).
机译：致编辑：中东呼吸综合征冠状病毒（MERS-CoV）于2012年首次在人类中诊断出。MERS-CoV在人与人之间的传播受到限制，并且传播途径仍不清楚。在流行病学研究的基础上，已经提出了动物宿主的参与（1）。根据MERS-CoV抗体和呼吸拭子样品中MERS-CoV病毒RNA的检测，单峰骆驼已被确定为可能的中间宿主（1-3）。此外，从单峰骆驼获得的MERS-CoV基因组序列与从同一个农场相连的人获得的MERS-CoV序列聚在一起（2）。尽管如此，大多数患有MERS-CoV的人并未报告与单峰骆驼有任何直接接触。因此，尚不清楚MERS-CoV人畜共患病的传播方式。 MERS-CoV在起源于多种不同宿主的细胞系中复制，这表明了目前公认的更广泛的储集层物种潜力（4）。但是，与单峰骆驼不同，在山羊，绵羊和母牛中未发现任何指向MERSCoV感染的血清学证据（1）。奶制品的污染与细菌和病毒的传播有关。在山羊进行实验性感染后，牛奶中发现了传染性tick传播性脑炎病毒的脱落，并且食用生乳与tick传播性脑炎病毒簇有关（5）。同样，牛可以通过食用受污染的原奶来感染口蹄疫（6）。

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