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Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989–2014

机译：1989-2014年与丙泊酚被污染的麻醉有关的传染病风险

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Administration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive strategies. In this overview of the evidence of propofol as a source of infection and appraisal of preventive strategies, we identified 58 studies through a literature search in PubMed, Embase, and Lilacs for propofol-related infections during 1989–2014. Twenty propofol-related outbreaks have been reported, affecting 144 patients and resulting in 10 deaths. Related factors included reuse of syringes for multiple patients and prolonged exposure to the environment when vials were left open. The addition of antimicrobial drugs to the emulsion has been instituted in some countries, but outbreaks have still occurred. There remains a lack of comprehensive information on the effectiveness of measures to prevent future outbreaks.
机译：尽管丙泊酚是相对安全的，但它是全世界最常用的静脉麻醉药，与多种医源性感染有关。关于异丙酚相关疾病的全球流行病学以及现有预防策略的有效性，人们所知甚少。在对丙泊酚作为感染源和预防策略评估的证据的概述中，我们通过在PubMed，Embase和Lilacs中对1989-2014年期间与异丙酚相关的感染进行了文献检索，确定了58项研究。据报道有20起与异丙酚有关的暴发，影响了144名患者，导致10人死亡。相关因素包括多位患者可重复使用注射器以及小瓶打开时长时间暴露于环境中。在一些国家已经开始在乳状液中添加抗微生物药物，但仍在爆发。关于防止未来爆发的措施的有效性，仍然缺乏全面的信息。

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