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首页> 外文期刊>Emerging Infectious Diseases >Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010
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Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010

机译：爆发期间分离出的Mayaro病毒株的进化和生态特征，委内瑞拉，2010年

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In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acute-phase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.
机译：2010年，在委内瑞拉的Portuguesa州的LaEstación村发现了带有关节痛表现的高热病暴发。确定病原为Mayaro病毒（MAYV），这是一种新兴的南美α病毒。总共报告了77例病例，其中19例被确认为血清阳性。从6例有症状患者的急性期血清样本中分离出MAYV。我们对代表MAYV遗传多样性全谱的27个完整基因组进行了测序，这有助于检测称为N的新基因型。基因组序列的系统发育分析表明，委内瑞拉的病原体属于基因型D。结果表明MAYV在遗传上高度保守，在所有可变基因中，在所有3个基因型中显示≈17％的核苷酸差异，在基因型D菌株中显示4％的核苷酸差异。合并分析表明，基因型D和L在大约150年前发生了分歧，而基因型在N大约250年前发生了分歧。由于人为入侵，该病毒通常感染居住在动物传播传播点附近的人。

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