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首页> 外文期刊>Emerging Infectious Diseases >Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes
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Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes

机译：人乳头瘤病毒疫苗接种计划对非疫苗基因型感染的人群水平影响。

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We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20–24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age groups and vaccines used were inconsistent, and the increases had possible alternative explanations; consequently, these data provided no clear evidence for type replacement. Continued monitoring of these HPV genotypes is important.
机译：我们分析了在疫苗接种前和疫苗接种后的人乳头瘤病毒（HPV）患病率，以考虑在引入可预防2种高危类型HPV16和HPV18的疫苗后，非疫苗HPV基因型的可能变化。我们的荟萃分析包括9项研究，数据包括13886名年龄在19岁以下的女孩和23340名20-24岁的女性。我们发现，在接种疫苗后的年轻年龄组中，HPV31有交叉保护的证据，但很少有证据表明HPV33和HPV45降低。对于同一年龄组的人群，我们还发现2种非疫苗高危型HPV（HPV39和HPV52）和2种可能的高危型（HPV53和HPV73）略有增加。但是，年龄组和所用疫苗之间的结果不一致，而且增加的值可能有其他解释。因此，这些数据没有提供明显的类型替代证据。持续监测这些HPV基因型很重要。

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