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首页> 外文期刊>Emerging Infectious Diseases >Bacillus cereus –Attributable Primary Cutaneous Anthrax-Like Infection in Newborn Infants, India
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Bacillus cereus –Attributable Primary Cutaneous Anthrax-Like Infection in Newborn Infants, India

机译：蜡状芽孢杆菌-印度新生儿的原发性皮肤炭疽样感染

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During March 13–June 23, 2018, anthrax-like cutaneous lesions attributed to the Bacillus cereus group of organisms developed in 12 newborns in India. We traced the source of infection to the healthcare kits used for newborn care. We used multilocus sequence typing to characterize the 19 selected strains from various sources in hospital settings, including the healthcare kits. This analysis revealed the existence of a genetically diverse population comprising mostly new sequence types. Phylogenetic analysis clustered most strains into the previously defined clade I, composed primarily of pathogenic bacilli. We suggest that the synergistic interaction of nonhemolytic enterotoxin and sphingomyelinase might have a role in the development of cutaneous lesions. The infection was controlled by removing the healthcare kits and by implementing an ideal housekeeping program. All the newborns recovered after treatment with ciprofloxacin and amikacin.
机译：在2018年3月13日至6月23日期间，印度的12个新生儿体内出现了炭疽杆菌样生物引起的类炭疽样皮肤病。我们将感染源追溯到用于新生儿护理的医疗工具包。我们使用多基因座序列分型来表征从医院环境中各种来源（包括医疗工具包）中选择的19种菌株。该分析揭示了主要由新序列类型组成的遗传多样性种群的存在。系统发育分析将大多数菌株聚集到先前定义的进化枝I中，该进化枝主要由致病杆菌组成。我们建议非溶血性肠毒素和鞘磷脂酶的协同相互作用可能在皮肤病变的发展中起作用。通过移除医疗工具包并实施理想的客房清洁程序来控制感染。环丙沙星和丁胺卡那霉素治疗后所有新生儿均恢复。

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