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Nature of the Virus Associated with Endemic Balkan Nephropathy

机译:与地方性巴尔干肾病有关的病毒的性质

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Endemic Balkan nephropathy (EBN), a disease restricted tothree Balkan countries (Bulgaria, Rumania, and Yugosla-via), is characterized by a progressive shrinking of the kidneysand, in some cases, tumors in the proximal regions of the uri-nary tract (1,2). A coronavirus was reported to be involved inthe etiology of the disease, mostly on the basis of the isolationof a virus in cultures of kidney cells from a patient with EBN(1,3). In addition, EBN-associated virus is reported to shareserologic homology with human coronaviruses OC43 and229E, as well as the porcine transmissible gastroenteritis coro-navirus (formal name: Transmissible gastroenteritis virus[TGEV]), a virus that our laboratory has been studying for 16years (4,5). The objective of this commentary is to clarifywhether the EBN-associated virus is in fact related to membersof the Coronaviridae family (6).
机译:巴尔干地方性肾病(EBN)是一种仅局限于三个巴尔干国家(保加利亚,罗马尼亚和南斯拉夫维亚地区)的疾病,其特征是肾脏逐渐萎缩,在某些情况下,尿道近端区域也有肿瘤( 1,2)。据报道,冠状病毒与该疾病的病因有关,主要是基于从患有EBN的患者的肾细胞培养物中分离出病毒(1,3)。此外,据报道,与EBN相关的病毒与人冠状病毒OC43和229E,以及猪可传播的胃肠炎冠状病毒(正式名称:可传播的胃肠炎病毒[TGEV])在股票学上具有同源性,这是我们实验室已研究16年的病毒(4,5)。本评论的目的是澄清与EBN相关的病毒是否实际上与冠状病毒科的成员有关(6)。

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