Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong (http://wwwnc.cdc.gov/eid/article/21/2/14-0623)

Susanna KP Lau; Alan KL Wu; Jade LL Teng; Herman Tse; Shirly OT Curreem; Stephen KW Tsui; Yi Huang; Jonathan HK Chen; Rodney A Lee; Kwok-Yung Yuen; Patrick CY Woo

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Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong (http://wwwnc.cdc.gov/eid/article/21/2/14-0623)

机译：香港伊丽莎白氏按蚊从母亲传播到婴儿的证据（http://wwwnc.cdc.gov/eid/article/21/2/14-0623）

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Elizabethkingia anophelis , recently discovered from mosquito gut, is an emerging bacterium associated with neonatal meningitis and nosocomial outbreaks. However, its transmission route remains unknown. We use rapid genome sequencing to investigate 3 cases of E. anophelis sepsis involving 2 neonates who had meningitis and 1 neonate’s mother who had chorioamnionitis. Comparative genomics revealed evidence for perinatal vertical transmission from a mother to her neonate; the 2 isolates from these patients, HKU37 and HKU38, shared essentially identical genome sequences. In contrast, the strain from another neonate (HKU36) was genetically divergent, showing only 78.6% genome sequence identity to HKU37 and HKU38, thus excluding a clonal outbreak. Comparison to genomes from mosquito strains revealed potential metabolic adaptations in E. anophelis under different environments. Maternal infection, not mosquitoes, is most likely the source of neonatal E. anophelis infections. Our findings highlight the power of genome sequencing in gaining rapid insights on transmission and pathogenesis of emerging pathogens.

机译：最近从蚊子肠道中发现的伊丽莎白女王按蚊是一种新兴细菌，与新生儿脑膜炎和医院内暴发有关。但是，其传输路径仍然未知。我们使用快速基因组测序来调查3例按蚊大肠杆菌败血症，其中涉及2例患有脑膜炎的新生儿和1例患有绒膜羊膜炎的新生儿。比较基因组学揭示了从母亲到新生儿的围产期垂直传播的证据。这些患者的2个分离株HKU37和HKU38具有基本相同的基因组序列。相比之下，来自另一名新生儿（HKU36）的菌株具有遗传差异，与HKU37和HKU38仅显示78.6％的基因组序列同一性，因此不包括克隆性爆发。与蚊子菌株的基因组比较表明，在不同环境下，按蚊的潜在代谢适应性强。产妇感染而不是蚊子最有可能是新生儿按蚊感染的来源。我们的发现凸显了基因组测序在快速了解新兴病原体的传播和发病机理方面的力量。

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《Emerging Infectious Diseases》 |2015年第2期|共10页
作者
Susanna KP Lau; Alan KL Wu; Jade LL Teng; Herman Tse; Shirly OT Curreem; Stephen KW Tsui; Yi Huang; Jonathan HK Chen; Rodney A Lee; Kwok-Yung Yuen; Patrick CY Woo;
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Evidence for Elizabethkingia anophelis Transmission from Mother to Infant, Hong Kong (http://wwwnc.cdc.gov/eid/article/21/2/14-0623)

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