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首页> 外文期刊>Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation >Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway
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Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway

机译：酿酒酵母细胞壁生物发生的调控：细胞壁完整性信号通路。

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摘要

The yeast cell wall is a strong, but elastic, structure that is essential not only for the maintenance of cell shape and integrity, but also for progression through the cell cycle. During growth and morphogenesis, and in response to environmental challenges, the cell wall is remodeled in a highly regulated and polarized manner, a process that is principally under the control of the cell wall integrity (CWI) signaling pathway. This pathway transmits wall stress signals from the cell surface to the [Rho1][1] GTPase, which mobilizes a physiologic response through a variety of effectors. Activation of CWI signaling regulates the production of various carbohydrate polymers of the cell wall, as well as their polarized delivery to the site of cell wall remodeling. This review article centers on CWI signaling in Saccharomyces cerevisiae through the cell cycle and in response to cell wall stress. The interface of this signaling pathway with other pathways that contribute to the maintenance of cell wall integrity is also discussed. [1]: http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006369
机译：酵母细胞壁是坚固但有弹性的结构，不仅对于维持细胞的形状和完整性，而且对于整个细胞周期的进展都是必不可少的。在生长和形态发生期间，以及响应环境挑战，细胞壁以高度调节和极化的方式重塑，该过程主要在细胞壁完整性（CWI）信号传导途径的控制下。该途径将壁应力信号从细胞表面传递至[Rho1] [1] GTPase，后者通过各种效应子动员生理反应。 CWI信号的激活调节细胞壁各种碳水化合物聚合物的产生，以及它们向细胞壁重塑部位的极化传递。这篇评论文章集中在酿酒酵母中通过细胞周期和对细胞壁压力的响应中的CWI信号传导。还讨论了该信号传导途径与其他有助于维持细胞壁完整性的途径的界面。 [1]：http：//www.yeastgenome.org/cgi-bin/locus.fpl？dbid = S000006369

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