Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.

J Field; D Broek; T Kataoka; M Wigler

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Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.

机译：来自酿酒酵母的RAS蛋白的鸟嘌呤核苷酸激活和竞争。

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In the yeast Saccharomyces cerevisiae, yeast RAS proteins are potent activators of adenylate cyclase. In the present work we measured the activity of adenylate cyclase in membranes from Saccharomyces cerevisiae which overexpress this enzyme. The response of the enzyme to added RAS2 proteins bound with various guanine nucleotides and their analogs suggests that RAS2 proteins are active in their GTP-bound form and are virtually inactive in their GDP-bound form. Also, active RAS2 protein is not inhibited by inactive RAS2, suggesting that the inactive form does not compete with the active form in binding to its effector.

机译：在酵母酿酒酵母中，酵母RAS蛋白是腺苷酸环化酶的有效激活剂。在目前的工作中，我们测量了酿酒酵母中过表达该酶的膜中腺苷酸环化酶的活性。酶对添加的与各种鸟嘌呤核苷酸结合的RAS2蛋白及其类似物的响应表明，RAS2蛋白以其GTP结合的形式起作用，而实际上以其GDP结合的形式没有活性。同样，活性RAS2蛋白也不会被非活性RAS2抑制，这表明该非活性形式在与其效应子结合方面不与该活性形式竞争。

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《Molecular and Cellular Biology》 |1987年第6期|共6页
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J Field; D Broek; T Kataoka; M Wigler;
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中图分类细胞生物学;
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1. The guanine-nucleotide-exchange factor P-Rex1 is activated by proteinTI The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1 alpha [J] . Barber MA, Hendrickx A, Beullens M, The Biochemical Journal . 2012,第Pta1期

机译：鸟嘌呤核苷酸交换因子P-Rex1被proteinTI激活。鸟嘌呤核苷酸交换因子P-Rex1被蛋白磷酸酶1 alpha激活。
2. Feedback regulation of Ras2 guanine nucleotide exchange factor (Ras2-GEF) activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces cerevisiae. [J] . Jian D, Aili Z, Xiaojia B, FEBS letters. . 2010,第23期

机译：酵母酿酒酵母中Cdc25p磷酸化对Cdc25p Ras2鸟嘌呤核苷酸交换因子（Ras2-GEF）活性的反馈调节。
3. Ssa1p chaperone interacts with the guanine nucleotide exchange factor of ras Cdc25p and controls the cAMP pathway in Saccharomyces cerevisiae. [J] . Geymonat M, Wang L, Garreau H, Molecular Microbiology . 1998,第4期

机译：Ssa1p伴侣分子与ras Cdc25p的鸟嘌呤核苷酸交换因子相互作用，并控制酿酒酵母中的cAMP途径。
4. THE INTERACTIONS OF BACTERIAL CELL DIVISION PROTEIN FtsZ WITH C8-SUBSTITUTED GUANINE NUCLEOTIDE INHIBITORS: NMR, BIOCHEMICAL AND MODEL INSIGHTS [C] . Marcelo. F., Huecas. S., Canada F.J. International Carbohydrate Symposium . 2013

机译：细菌细胞分裂蛋白FTSZ与C8取代的鸟嘌呤核苷酸抑制剂的相互作用：NMR，生物化学和模型见解
5. Mechanism of cellular transformation by the GTP-binding protein CDC42 and its activator, the guanine nucleotide exchange factor, DBL. [D] . Lin, Rui. 1999

机译：GTP结合蛋白CDC42及其激活剂鸟嘌呤核苷酸交换因子DBL进行细胞转化的机制。
6. Guanine nucleotide activation of and competition between RAS proteins from Saccharomyces cerevisiae. [O] . J Field, D Broek, T Kataoka, 1987

机译：来自酿酒酵母的RAS蛋白的鸟嘌呤核苷酸激活和竞争。
7. Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. [O] . Field, J, Broek, D, Kataoka, T, 1987

机译：来自酿酒酵母的RAS蛋白的鸟嘌呤核苷酸激活和竞争。

Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.

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