Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

R Ehrlich; J E Maguire; D S Singer

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Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

机译：鉴定与I类主要组织相容性复杂基因相关的阴性和阳性调节元件。

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Regulatory DNA sequence elements were functionally identified in the 5'-flanking region of a gene, PD1, which encodes a porcine classical transplantation antigen. Both a positive regulatory element and a novel negative regulatory DNA element were mapped within 1.1 kilobases upstream of exon 1. The negative regulatory element reduced the activity of both the homologous PD1 promoter and a heterologous simian virus 40 promoter. In vivo competition experiments indicated that the functions of the PD1 positive and negative regulatory elements are mediated by distinct cellular trans-acting factors. The PD1 positive regulatory element interacted with cellular factors in common with those binding to the simian virus 40 enhancer. Finally, the negative regulatory element required the presence of a positive regulatory element to function. This interaction between positive and negative regulatory elements represents a novel mechanism for regulating gene expression.

机译：在编码猪经典移植抗原的基因PD1的5'侧翼区域中，从功能上鉴定了调控DNA序列元件。正调控元件和新型负调控DNA元件均位于外显子1上游1.1 kb内。负调控元件降低了同源PD1启动子和异源猿猴病毒40启动子的活性。体内竞争实验表明，PD1正调控元件和负调控元件的功能由不同的细胞反式作用因子介导。 PD1阳性调控元件与与猿猴病毒40增强剂结合的细胞因子共同作用。最后，负调控元件需要存在正调控元件才能发挥作用。正负调节元件之间的这种相互作用代表了调节基因表达的新机制。

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《Molecular and Cellular Biology》 |1988年第2期|共9页
作者
R Ehrlich; J E Maguire; D S Singer;
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中图分类细胞生物学;
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专利

1. In vivo function of regulatory DNA sequence elements of a major histocompatibility complex class I gene. [J] . J E Maguire, W I Frels, J C Richardson, Molecular and Cellular Biology . 1992,第7期

机译：主要组织相容性复合体I类基因的调节性DNA序列元件的体内功能。
2. Developmental and tissue-specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene. [J] . P A Burke, S Hirschfeld, Y Shirayoshi, The Journal of Experomental Medicine . 1989,第4期

机译：结合主要组织相容性复合体I类基因调控元件的核蛋白的发育和组织特异性表达。
3. Binding of multiple nuclear factors to the 5' upstream regulatory element of the murine major histocompatibility class I gene. [J] . Y Shirayoshi, J Miyazaki, P A Burke, Molecular and Cellular Biology . 1987,第12期

机译：多种核因子与鼠类主要组织相容性I类基因的5'上游调控元件的结合。
4. Population Structure and Stock Identification of Chum Salmon from Western Alaska Determined with Microsatellite DNA and Major Histocompatibility ComplexVariation [C] . Terry D. Beacham, Khai D. Le, Michael Wetklo, Symposium "Sustainability of the Arctic-Yukon-Kuskokwim Salmon Fisheries . 2009

机译：从西阿拉斯加西部的人口结构和股票鉴定用微卫星DNA测定和主要组织相容性复合性
5. Major histocompatibility complex class I is a negative regulator of neuronal insulin receptor signaling and hippocampal synapse number. [D] . Dixon Salazar, Tracy Jean. 2009

机译：I类主要组织相容性复合物是神经元胰岛素受体信号传导和海马突触数量的负调节剂。
6. Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene. [O] . R Ehrlich, J E Maguire, D S Singer 1988

机译：鉴定与I类主要组织相容性复杂基因相关的阴性和阳性调节元件。
7. Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene. [O] . Ehrlich, R, Maguire, J E, Singer, D S 1988

机译：鉴定与I类主要组织相容性复杂基因相关的阴性和阳性调节元件。
8. Recognition and Response to Alloantigens In Vivo. I. Negative and Positive Selection of MLR (Mixed Lymphocyte Reaction) Reactivity in Murine Peripheral Blood Lymphocytes to Major Histocompatibility Complex and MLS (Minor Lymphocyt [R] . Ryan, J. J., Kind, P. D., Thompson, C. B., 1984

机译：对体内同种异体抗原的识别和反应。 I.小鼠外周血淋巴细胞与主要组织相容性复合物和mLs（小淋巴细胞）的mLR（混合淋巴细胞反应）反应性的阴性和阳性选择

Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

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