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首页> 外文期刊>Molecular and Cellular Biology >Molecular analysis of hybrid dysgenesis-induced derivatives of a P-element allele at the vg locus.
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Molecular analysis of hybrid dysgenesis-induced derivatives of a P-element allele at the vg locus.

机译：在vg位点杂化发育不全诱导的P元素等位基因衍生物的分子分析。

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摘要

Secondary and tertiary derivatives of a P-element insertion allele at the vestigial (vg) locus were induced by hybrid dysgenesis. The derivatives were characterized by Southern analyses and, in four cases, by DNA sequencing. The alterations found were P-element internal deletions, deletions of the insert and/or adjacent vg region DNA, or novel insertions of P-element sequences into existing P-element inserts. The relatively high frequency of secondary insertions into P-element sequences observed herein is unusual, since secondary insertions have seldom been recovered in other dysgenic screens. The effects of the alleles on vg expression were determined. The results are consistent with a model in which the insertions disrupt vg gene expression by transcriptional interference.
机译：杂种发育不全诱导在残留（vg）位点的P元素插入等位基因的二级和三级衍生物。通过Southern分析和在四种情况下通过DNA测序来表征衍生物。发现的改变是P元素内部缺失，插入物和/或相邻vg区DNA的缺失，或P元素序列向现有P元素插入物中的新插入。本文观察到的相对较高的二次插入P元素序列的频率是不寻常的，因为二次插入很少在其他致孕筛查中被发现。确定了等位基因对vg表达的影响。结果与其中插入通过转录干扰破坏vg基因表达的模型一致。

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