Structure and biological activity of human homologs of the raf/mil oncogene.

T I Bonner; S B Kerby; P Sutrave; M A Gunnell; G Mark; U R Rapp

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Structure and biological activity of human homologs of the raf/mil oncogene.

机译：raf / mil癌基因的人类同源物的结构和生物学活性。

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Two human genes homologous to the raf/mil oncogene have been cloned and sequenced. One, c-raf-2, is a processed pseudogene; the other, c-raf-1, contains nine exons homologous to both raf and mil and two additional exons homologous to mil. A 3' portion of c-raf-1 containing six of the seven amino acid differences relative to murine v-raf can substitute for the 3' portion of v-raf in a transformation assay. Sequence homologies between c-raf-1 and Moloney leukemia virus at both ends of v-raf indicate that the viral gene was acquired by homologous recombination. Although the data are consistent with the traditional model of retroviral transduction, they also raise the possibility that the transduction occurred in a double crossover event between proviral DNA and the murine gene.

机译：与raf / mil致癌基因同源的两个人类基因已被克隆并测序。一个是c-raf-2，是一个经过处理的伪基因。另一个c-raf-1包含9个与raf和mil同源的外显子，以及另外两个与mil同源的外显子。在转化试验中，相对于鼠类v-raf含有7个氨基酸差异中的6个氨基酸的c-raf-1的3'部分可以替代v-raf的3'部分。 v-raf两端的c-raf-1与莫洛尼白血病病毒之间的序列同源性表明，该病毒基因是通过同源重组获得的。尽管数据与逆转录病毒转导的传统模型一致，但它们也增加了转导发生在前病毒DNA与鼠类基因之间的双重交叉事件中的可能性。

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《Molecular and Cellular Biology》 |1985年第6期|共8页
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T I Bonner; S B Kerby; P Sutrave; M A Gunnell; G Mark; U R Rapp;
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中图分类细胞生物学;
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6. Structure and biological activity of human homologs of the raf/mil oncogene. [O] . T I Bonner, S B Kerby, P Sutrave, 1985

机译：raf / mil癌基因的人类同源物的结构和生物学活性。
7. Structure and biological activity of human homologs of the raf/mil oncogene. [O] . Bonner, T I, Kerby, S B, Sutrave, P, 1985

机译：raf / mil癌基因的人类同源物的结构和生物学活性。

Structure and biological activity of human homologs of the raf/mil oncogene.

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