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首页> 外文期刊>Molecular and Cellular Biology >Transcription and translation of mitochondrial DNA in interspecific somatic cell hybrids.
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Transcription and translation of mitochondrial DNA in interspecific somatic cell hybrids.

机译：种间体细胞杂种中线粒体DNA的转录和翻译。

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We examined the mitochondrial transcription and translation products of somatic cell hybrids constructed by the fusion of Chinese hamster and mouse cells. The hybrid cell lines OAC-k, OAC-l, and OAC-m contain approximately equal amounts of hamster and mouse mitochondrial DNA and produced mitochondrial rRNA from both parental species in the same ratio. Cell lines OAC-k, OAC-l, and OAC-m also produced poly(A)+ mouse mitochondrial RNA transcripts comparable in complexity and quantity to poly(A)+ RNA from the mouse parent. However, the overall level of poly(A)+ hamster mitochondrial RNA from these hybrids was significantly reduced compared with that from the hamster parent. The hybrid cells also lacked several poly(A)+ RNA species found in the hamster parent, but contained additional minor transcripts. The mitochondrially coded proteins of the OAC-k, OAC-l, and OAC-m cells were predominantly encoded by the mouse mitochondrial DNA.
机译：我们检查了由中国仓鼠和小鼠细胞融合构建的体细胞杂种的线粒体转录和翻译产物。杂种细胞系OAC-k，OAC-1和OAC-m包含大约等量的仓鼠和小鼠线粒体DNA，并以相同比例从两个亲本物种产生线粒体rRNA。细胞系OAC-k，OAC-1和OAC-m还产生了与小鼠亲本的poly（A）+ RNA相当的复杂性和数量可比的poly（A）+小鼠线粒体RNA转录本。但是，与仓鼠亲本相比，这些杂种的poly（A）+仓鼠线粒体RNA的总体水平显着降低。杂种细胞也缺乏仓鼠亲本中发现的几种poly（A）+ RNA种类，但还包含其他次要转录物。 OAC-k，OAC-1和OAC-m细胞的线粒体编码蛋白主要由小鼠线粒体DNA编码。

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