A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter.

L S Lum; L A Sultzman; R J Kaufman; D I Linzer; B J Wu

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A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter.

机译：克隆的人CCAAT盒结合因子刺激人hsp70启动子的转录。

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The basal promoter of the human hsp70 gene is predominantly controlled by a CCAAT element at position -70 relative to the transcriptional initiation site. We report the isolation of a novel cDNA clone encoding a 114-kDa polypeptide that binds to the CCAAT element of the hsp70 promoter. Expression of this CCAAT-binding factor (CBF) cDNA activated transcription from cotransfected hsp70 promoter-reporter gene constructs in a CCAAT-dependent manner. CCAAT-binding factor shows no homology to the previously identified human CCAAT transcription factor or rat CCAAT/enhancer-binding protein.

机译：人hsp70基因的基础启动子主要由相对于转录起始位点-70位的CCAAT元件控制。我们报告了编码与hsp70启动子的CCAAT元素结合的114 kDa多肽的新型cDNA克隆的分离。此CCAAT结合因子（CBF）cDNA的表达以CCAAT依赖性方式激活了共转染的hsp70启动子-报告基因构建体的转录。 CCAAT结合因子与先前鉴定的人CCAAT转录因子或大鼠CCAAT /增强子结合蛋白没有同源性。

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《Molecular and Cellular Biology》 |1990年第12期|共9页
作者
L S Lum; L A Sultzman; R J Kaufman; D I Linzer; B J Wu;
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中图分类细胞生物学;
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1. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. [J] . W D Morgan, G T Williams, R I Morimoto, Molecular and Cellular Biology . 1987,第3期

机译：两种转录激活因子CCAAT盒结合转录因子和热休克转录因子与人类hsp70基因启动子相互作用。
2. Transcription factor Sp1 binds to and activates a human hsp70 gene promoter. [J] . W D Morgan Molecular and Cellular Biology . 1989,第9期

机译：转录因子Sp1结合并激活人类hsp70基因启动子。
3. Heat-inducible human factor that binds to a human hsp70 promoter. [J] . R E Kingston, T J Schuetz, Z Larin Molecular and Cellular Biology . 1987,第4期

机译：与人hsp70启动子结合的热诱导人因子。
4. Transcriptome (RNA-seq) analysis of human salivary gland cells with exogenous expression of human pancreas beta cells transcription factors PDX1, MAFA, NGN3 [C] . Olga Brovkina, Yulia Kolesova, Mikhail Borisov, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：外源表达人胰腺β细胞转录因子PDX1，MAFA，NGN3的人唾液腺细胞的转录组（RNA-seq）分析
5. Regulation of human macrophage colony -stimulating factor transcription [D] . Kamthong, Pisate John 2001

机译：人类巨噬细胞集落刺激因子转录的调控
6. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. [O] . L S Lum, L A Sultzman, R J Kaufman, 1990

机译：克隆的人CCAAT盒结合因子刺激人hsp70启动子的转录。
7. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. [O] . Lum, L S, Sultzman, L A, Kaufman, R J, 1990

机译：克隆的人CCAAT盒结合因子刺激人hsp70启动子的转录。
8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter.

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