Interleukin 1 regulates human metallothionein gene expression.

M Karin; R J Imbra; A Heguy; G Wong

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Interleukin 1 regulates human metallothionein gene expression.

机译：白介素1调节人金属硫蛋白基因表达。

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摘要

Incubation of cultured human cells with interleukin 1 leads to increased expression of the human metallothionein-IIA gene. Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals.

机译：将培养的人细胞与白介素1一起孵育会导致人金属硫蛋白IIA基因的表达增加。最近，金属硫蛋白已被证明是一种有效的自由基清除剂，白介素1的诱导可能是保护性反应的一部分，可最大程度地减少羟基自由基的破坏。

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《Molecular and Cellular Biology》 |1985年第10期|共4页
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M Karin; R J Imbra; A Heguy; G Wong;
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中图分类细胞生物学;
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1. Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: implications for mechanisms regulating metallothionein gene expression. [J] . B D Crawford, M D Enger, B B Griffith, Molecular and Cellular Biology . 1985,第2期

机译：耐镉的中国仓鼠细胞中金属硫蛋白I和II基因的协调扩增：对调节金属硫蛋白基因表达的机制的影响。
2. Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression. [J] . John GR, Simpson JE, Woodroofe MN, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2001,第12期

机译：细胞外核苷酸差异调节原代人星形胶质细胞中白介素1β信号传导：对炎症基因表达的影响。
3. Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. [J] . Lee DK, Carrasco J, Hidalgo J, The Biochemical Journal . 1999,第Pta1期

机译：鉴定涉及白介素6诱导的基因表达的小鼠金属硫蛋白-I启动子中的信号转导子和转录激活子（STAT）结合位点。
4. Interleukin-1 Alpha Regulates VEGF Production from Gastric Cancer Cell Lines and Relation to Angiogenesis [C] . Matsuo Y., Wakasugi T., Funahashi H., International Gastric Cancer Congress . 2011

机译：白细胞介素-1α调节胃癌细胞系的VEGF生产和与血管生成的关系
5. Intracellular Signal Transduction Mechanisms Regulating the Activation of Human Bronchial Epithelial Cells by Interleukin-17A, Interleukin-27, Tumor Necrosis Factor-alpha and Human Basophils in Inflammatory Diseases [D] . Cao, Ju 2010

机译：调节人白细胞介素17A，白细胞介素27，肿瘤坏死因子-α和人类嗜碱性粒细胞在炎性疾病中激活人支气管上皮细胞的细胞内信号转导机制
6. Interleukin 1 regulates human metallothionein gene expression. [O] . M Karin, R J Imbra, A Heguy, 1985

机译：白介素1调节人类金属硫蛋白基因表达。
7. Interleukin 1 regulates human metallothionein gene expression. [O] . Karin, M, Imbra, R J, Heguy, A, 1985

机译：白介素1调节人类金属硫蛋白基因表达。

Interleukin 1 regulates human metallothionein gene expression.

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