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首页> 外文期刊>Molecular and Cellular Biology >Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription.
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Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription.

机译：人类COLO 320细胞中扩增的c-myc 5'末端的重排与异常转录有关。

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摘要

The proto-oncogene c-myc is amplified in sublines of human COLO 320 cells carrying either homogeneously staining chromosomal regions or double minutes. COLO 320 cells carrying homogeneously staining chromosomal regions have 15 to 20 copies of an apparently normal c-myc allele and 1 to 2 copies of an abnormal c-myc allele lacking exon 1 and express high levels of a normal c-myc mRNA 2.5 kilobases in size. COLO 320 cells carrying double minutes have about 25 copies each of the normal allele and the abnormal allele but express preferentially an abnormal c-myc mRNA 2.2 kilobases in size. Nucleotide sequence analyses revealed that the break point of rearrangement resulting in the loss of exon 1 in the abnormal allele lies within a region frequently rearranged in human and murine B-cell tumors.
机译：原癌基因c-myc在人COLO 320细胞的亚系中扩增，这些亚细胞携带均一染色的染色体区域或两分钟。携带均质染色染色体区域的COLO 320细胞具有15至20份看似正常的c-myc等位基因，以及1至2份缺少外显子1的异常c-myc等位基因，并在2.5 kb中表达高水平的正常c-myc mRNA。尺寸。进行了两分钟的COLO 320细胞每个正常等位基因和异常等位基因均约有25个拷贝，但优先表达2.2 kb的异常c-myc mRNA。核苷酸序列分析显示，导致异常等位基因中外显子1丢失的重排断裂点位于人和鼠B细胞肿瘤中经常重排的区域内。

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