Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

E J Lewis; D M Chikaraishi

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Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

机译：表皮生长因子调节酪氨酸羟化酶基因的表达。

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The addition of epidermal growth factor (EGF) to cultures of the rat PCG2 pheochromocytoma cell line increased the level of RNA coding for tyrosine hydroxylase (TH). A region of DNA containing 5'-flanking sequences of the TH gene was fused to a heterologous gene and transfected into a rat anterior pituitary cell line, GH4. The TH gene sequences from +27 to -272 contained information sufficient for the induction of TH by EGF. Two regions within this TH DNA were extensively homologous to the EGF regulatory element of the rat prolactin gene.

机译：向大鼠PCG2嗜铬细胞瘤细胞系的培养物中添加表皮生长因子（EGF）可提高编码酪氨酸羟化酶（TH）的RNA水平。将含有TH基因5'侧翼序列的DNA区域与异源基因融合，并转染到大鼠垂体前叶细胞系GH4中。从+27到-272的TH基因序列包含足以通过EGF诱导TH的信息。该TH DNA内的两个区域与大鼠催乳素基因的EGF调节元件广泛同源。

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《Molecular and Cellular Biology》 |1987年第9期|共5页
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E J Lewis; D M Chikaraishi;
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中图分类细胞生物学;
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6. Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. [O] . E J Lewis, D M Chikaraishi 1987

机译：表皮生长因子调节酪氨酸羟化酶基因的表达。
7. Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. [O] . Lewis, E J, Chikaraishi, D M 1987

机译：表皮生长因子调节酪氨酸羟化酶基因的表达。

Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

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