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首页> 外文期刊>Molecular and Cellular Biology >Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos.
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Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos.

机译：小鼠锌指基因Krox-20的结构，染色体位置和表达：多种基因产物并与原癌基因c-fos共调节。

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摘要

We have analyzed the structure and the regulation of Krox-20, a mouse zinc finger-encoding gene which is transiently activated following serum stimulation of quiescent fibroblast cells in culture. The gene is localized on chromosome 10, band B5, in the mouse, and the homologous human gene also maps to chromosome 10 (region q21.1 to q22.1). Alternative splicing of the 5'-most intron of the Krox-20 gene gives rise to mRNAs encoding putative zinc finger proteins with different N termini. The first exon contains a sequence element with strong similarity to the c-fos proto-oncogene serum response element (SRE). This element can functionally substitute for the c-fos SRE, and it binds the same nuclear protein. It is probably responsible for the serum induction of Krox-20, possibly in combination with a weaker SRE located in the 5'-flanking region of the gene. Our findings suggest that c-fos, Krox-20, and a number of immediate-early serum response genes are coregulated and that the SRE and its cognate protein are essential components of this regulatory pathway.
机译：我们已经分析了Krox-20的结构和调控，Krox-20是小鼠锌指编码基因，在血清刺激培养物中的静止成纤维细胞后被瞬时激活。该基因位于小鼠的10号染色体B5带上，同源的人类基因也映射到10号染色体（q21.1至q22.1区域）。 Krox-20基因的5'-最内含子的可变剪接产生编码带有不同N末端的假定锌指蛋白的mRNA。第一个外显子包含与c-fos原癌基因血清反应元件（SRE）高度相似的序列元件。该元素可以在功能上替代c-fos SRE，并且可以结合相同的核蛋白。它可能与Krox-20的血清诱导有关，可能与基因5'侧翼区域中较弱的SRE相结合。我们的发现表明，c-fos，Krox-20和许多立即早期的血清反应基因被共调节，并且SRE及其同源蛋白是该调节途径的重要组成部分。

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