• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein.
【24h】

SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein.

机译：SSC1是酵母HSP70多基因家族的重要成员，它编码线粒体蛋白。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SSC1 is an essential member of the yeast HSP70 multigene family (E. Craig, J. Kramer, and J. Kosic-Smithers, Proc. Natl. Acad. Sci. USA 84:4156-4160, 1987). Analysis of the SSC1 DNA sequence revealed that it could encode a 70,627-dalton protein that is more similar to DnaK, an Escherichia coli hsp70 protein, than other yeast hsp70s whose sequences have been determined. Ssc1p was found to have an amino-terminal extension of 28 amino acids, in comparison with either Ssa1p, another hsp70 yeast protein, or Dnak. This putative leader is rich in basic and hydroxyl amino acids, characteristic of many mitochondrial leader sequences. Ssc1p that was synthesized in vitro could be imported into mitochondria and was cleaved in the process. The imported protein comigrated with an abundant mitochondrial protein that reacted with hsp70-specific antibodies. We conclude that Ssc1p is a mitochondrial protein and that hsp70 proteins perform functions in many compartments of the cell.
机译：SSC1是酵母HSP70多基因家族的重要成员（E. Craig，J。Kramer和J. Kosic-Smithers，美国国家科学院院刊84：4156-4160，1987）。对SSC1 DNA序列的分析表明，与已确定序列的其他酵母hsp70s相比，它可以编码70,627道尔顿的蛋白质，与大肠埃希氏菌hsp70蛋白质DnaK更相似。与Ssa1p，另一种hsp70酵母蛋白或Dnak相比，发现Ssc1p具有28个氨基酸的氨基末端延伸。该推定的前导序列富含碱性和羟基氨基酸，这是许多线粒体前导序列的特征。体外合成的Ssc1p可以导入线粒体并在此过程中裂解。导入的蛋白质与丰富的线粒体蛋白质竞争，后者与hsp70特异性抗体反应。我们得出的结论是Ssc1p是一种线粒体蛋白，hsp70蛋白在细胞的许多区室中发挥功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号