Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.

R Dikstein; O Faktor; Y Shaul

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Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.

机译：大鼠肝核蛋白C / EBP在乙型肝炎病毒增强剂上的层次和合作结合。

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We used the enhancer-binding protein C/EBP as a model to study the nature and the complexity of interaction of an enhancer-binding protein with its target DNA. We found that bacterially expressed C/EBP binds the hepatitis B virus enhancer at multiple sites in a hierarchic and cooperative manner. At low concentrations, only the E element is occupied, but at higher concentrations, additional sites are filled including a site that binds EP, a crucial enhancer-activating protein. This pattern of C/EBP binding may explain the concentration-dependent effect of C/EBP on enhancer activity.

机译：我们使用增强子结合蛋白C / EBP作为模型来研究增强子结合蛋白与其靶DNA相互作用的性质和复杂性。我们发现，细菌表达的C / EBP以分层和协作的方式在多个位置结合了乙型肝炎病毒增强剂。在低浓度下，仅E元素被占据，而在高浓度下，其他位点被填充，包括与EP（一种关键的增强子激活蛋白）结合的位点。 C / EBP结合的这种模式可能解释了C / EBP对增强子活性的浓度依赖性作用。

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《Molecular and Cellular Biology》 |1990年第8期|共4页
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R Dikstein; O Faktor; Y Shaul;
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中图分类细胞生物学;
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2. Protein-x of hepatitis B virus in interaction with CCAAT/enhancer-binding protein α (C/EBPα) - an in silico analysis approach [J] . Ashraf Mohamadkhani, Parisa Shahnazari, Zarrin Minuchehr, Theoretical Biology and Medical Modelling . 2011,第1期

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6. Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer. [O] . R Dikstein, O Faktor, Y Shaul 1990

机译：在乙型肝炎病毒增强剂上大鼠肝核蛋白C / EBP的层次和合作结合。
7. Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer. [O] . Dikstein, R, Faktor, O, Shaul, Y 1990

机译：在乙型肝炎病毒增强剂上大鼠肝核蛋白C / EBP的层次和合作结合。
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Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.

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