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首页> 外文期刊>Molecular and Cellular Biology >Interrelationships of protein and DNA syntheses during replication of mammalian cells.
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Interrelationships of protein and DNA syntheses during replication of mammalian cells.

机译：哺乳动物细胞复制过程中蛋白质和DNA合成的相互关系。

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摘要

During the replication of chromatin, the syntheses of the histone protein and DNA components are closely coordinated but not totally linked. The interrelationships of total protein synthesis, histone protein synthesis, DNA synthesis, and mRNA levels have been investigated in Chinese hamster ovary cells subjected to several different types of inhibitors in several different temporal combinations. The results from these studies and results reported elsewhere can be brought together into a consistent framework which combines the idea of autoregulation of histone biosynthesis as originally proposed by W. B. Butler and G. C. Mueller (Biochim. Biophys. Acta 294:481-496, 1973] with the presence of basal histone synthesis and the effects of protein synthesis on DNA synthesis. The proposed framework obviates the difficulties of Butler and Mueller's model and may have wider application in understanding the control of cell growth.
机译：在染色质复制过程中，组蛋白和DNA成分的合成紧密协调，但并不完全相连。已经研究了中国仓鼠卵巢细胞中总蛋白合成，组蛋白合成，DNA合成和mRNA水平之间的相互关系，这些细胞以几种不同的时间组合经受了几种不同类型的抑制剂。这些研究的结果和其他地方报告的结果可以整合到一个一致的框架中，该框架结合了WB Butler和GC Mueller最初提出的组蛋白生物合成自动调节的想法（Biochim。Biophys。Acta 294：481-496，1973]，该框架消除了Butler和Mueller模型的困难，在理解细胞生长控制方面可能具有更广泛的应用。

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