Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus.

L Simonneau; P Crisanti; A M Lorinet; F Alliot; Y Courtois; G Calothy; B Pessac

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Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus.

机译：在由致癌逆转录病毒Mill Hill 2或Rous肉瘤病毒转化的鹌鹑胚胎神经视网膜培养物中Crystallin基因表达和类凸体形成。

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The lens-specific proteins alpha and delta crystallins and lentoid bodies, structures that follow a differentiation pathway similar to that of the lens, regularly appear after 4 to 5 weeks in quail embryo neuroretina monolayer cultures. We have investigated the effects of the avian oncogenic retroviruses Mill Hill 2 and Rous sarcoma virus on this process. Quail embryo neuroretina cells transformed by Mill Hill 2 virus were established into permanent cultures that synthesized alpha and delta crystallins and contained stem cells for the production of lentoid bodies. In contrast, transformation with the Rous sarcoma virus mutant tsNY-68 blocked the appearance of mRNA crystallins, but cytoplasmic alpha and delta crystallin mRNA and alpha crystallin appeared 44 h after a shift to the nonpermissive temperature. However, delta crystallins and lentoid bodies were only present after 7 days. The crystallins of transformed quail neuroretina cultures were immunologically indistinguishable from those of quail lenses and of normal quail embryo neuroretina cultures.

机译：在鹌鹑胚胎神经视网膜单层培养物中，晶状体特异性蛋白α和δ晶状体蛋白以及类突体结构（遵循与晶状体相似的分化途径）通常在4至5周后出现。我们已经研究了禽致癌逆转录病毒Mill Hill 2和Rous肉瘤病毒对该过程的影响。将通过Mill Hill 2病毒转化的鹌鹑胚胎神经视网膜细胞建立到永久性培养物中，该培养物合成了alpha和delta晶状体蛋白，并包含干细胞以产生双凸体。相比之下，用劳斯肉瘤病毒突变体tsNY-68进行的转化可阻止mRNA晶状体蛋白的出现，但细胞质的α和δ晶状体蛋白mRNA和α晶状体蛋白在转移至非容许温度后44小时出现。但是，仅7天后才出现δ晶状体蛋白和双凸体。从免疫学上看，与鹌鹑晶状体和正常鹌鹑胚胎神经视网膜培养物的结晶蛋白在免疫学上没有区别。

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《Molecular and Cellular Biology》 |1986年第11期|共7页
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L Simonneau; P Crisanti; A M Lorinet; F Alliot; Y Courtois; G Calothy; B Pessac;
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1. Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus. [J] . L Simonneau, P Crisanti, A M Lorinet, Molecular and Cellular Biology . 1986,第11期

机译：在由致癌逆转录病毒Mill Hill 2或Rous肉瘤病毒转化的鹌鹑胚胎神经视网膜培养物中Crystallin基因表达和类凸体形成。
2. Differentiation of Quail Myoblasts Transformed with a Temperature Sensitive Mutant of Rous Sarcoma Virus. I. Relationship between Differentiation and Tyrosine Kinase of src Gene Product [J] . Etsuko Hirayama, Jeman Kim, Tadaaki Yabubayashi, Cell structure and function . 1992,第4期

机译：劳斯肉瘤病毒温度敏感突变体转化的鹌鹑成肌细胞的分化。 I. src基因产物的分化与酪氨酸激酶的关系
3. Transformation-sensitive isoactin in passaged chick embryo fibroblasts transformed by Rous sarcoma virus. [J] . D P Witt, D J Brown, J A Gordon Journal of cell biology . 1983,第6期

机译：劳斯肉瘤病毒转化的传代鸡胚成纤维细胞中的转化敏感性异肌动蛋白。
4. Jaagsiekte sheep retrovirus proteins in oncogenic transformation and regulation of viral gene expression. [D] . Hofacre, Andrew Gene. 2008

机译：Jaagsiekte绵羊逆转录病毒蛋白在致癌性转化和病毒基因表达调控中的作用。
5. Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus. [O] . L Simonneau, P Crisanti, A M Lorinet, 1986

机译：在由致癌逆转录病毒Mill Hill 2或Rous肉瘤病毒转化的鹌鹑胚胎神经视网膜培养物中Crystallin基因表达和类凸体形成。
6. Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus. [O] . Simonneau, L, Crisanti, P, Lorinet, A M, 1986

机译：在由致癌逆转录病毒Mill Hill 2或Rous肉瘤病毒转化的鹌鹑胚胎神经视网膜培养物中Crystallin基因表达和类凸体形成。

Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus.

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