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DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.

机译:编码人c-src蛋白氨基末端区域的DNA序列:src型激酶致癌基因之间序列差异的含义。

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摘要

We sequenced the 5'-coding region of the human c-src gene, exons 2 through 5, corresponding to one-third of the human c-src protein consisting of 536 amino acids. Sequence analysis of the src type of protein kinases revealed that the amino-terminal region encoded by exon 2 contains sequences specific for the src proteins and raised the possibility that this region is involved in the recognition of a src-specific substrate(s) or receptor(s).
机译:我们对人c-src基因的5'编码区(外显子2至5)进行了测序,对应于由536个氨基酸组成的人c-src蛋白的三分之一。 src型蛋白激酶的序列分析表明,外显子2编码的氨基末端区域含有src蛋白特异的序列,并增加了该区域参与src特异性底物或受体识别的可能性(s)。

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