• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development.
【24h】

Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development.

机译：母体细胞质c-myc蛋白在早期发育过程中转移到细胞核中。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The c-myc proto-oncogene is expressed as a maternal protein during oogenesis in Xenopus laevis, namely, in nondividing cells. A delayed translation of c-myc mRNA accumulated in early oocytes results in the accumulation of the protein during late oogenesis. The oocyte c-myc protein is unusually stable and is located in the cytoplasm, contrasting with its features in somatic cells. A mature oocyte contains a maternal c-myc protein stockpile of 4 x 10(5) to 6 x 10(5) times the level in a somatic growing cell. This level of c-myc protein is preserved only during the cleavage stage of the embryo. Fertilization triggers its rapid migration into the nuclei of the cleaving embryo and a change in the phosphorylation state of the protein. The c-myc protein content per nucleus decreases exponentially during the cleavage stage until a stoichiometric titration by the embryonic nuclei is reached during a 0.5-h period at the midblastula stage. Most of the maternal c-myc store is degraded by the gastrula stage. These observations implicate the participation of c-myc in the events linked to early embryonic development and the midblastula transition.
机译：c-myc原癌基因在非洲爪蟾，即非分裂细胞的卵子发生过程中作为母体蛋白表达。在早期卵母细胞中积累的c-myc mRNA的翻译延迟会导致在晚期卵子发生过程中蛋白质的积累。卵母细胞c-myc蛋白异常稳定并位于细胞质中，与其在体细胞中的功能形成鲜明对比。成熟的卵母细胞的母体c-myc蛋白储备量是体细胞生长细胞水平的4 x 10（5）至6 x 10（5）倍。仅在胚胎切割阶段才保留此水平的c-myc蛋白。受精会触发其快速迁移到分裂胚胎的核中，并使蛋白质的磷酸化状态发生变化。在裂解阶段，每个核的c-myc蛋白含量呈指数下降，直到在胚泡中期的0.5小时内达到胚胎核的化学计量滴定。产妇的c-myc储存库大多数会在下腹阶段降解。这些观察结果暗示c-myc参与与早期胚胎发育和中胚层过渡有关的事件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号