Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.

S Verbeek; M van Lohuizen; M van der Valk; J Domen; G Kraal; A Berns

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Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.

机译：带有E mu-myc和E mu-pim-1转基因的小鼠在出生前会发展为B细胞白血病。

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Previously, it has been shown that E mu-pim-1 transgenic mice are predisposed to T-cell lymphomas, whereas E mu-myc transgenic mice are predisposed to pre-B-cell lymphomas. Here we show that double-transgenic E mu-myc E mu-pim-1 mice exhibit pre-B-cell leukemia in utero. Upon transplantation into recipient mice, embryo-derived double-transgenic leukemic cells frequently progressed to highly malignant monoclonal tumors, indicating that additional (epi)genetic events had occurred during the progression of the disease.

机译：以前，已经表明E mu-pim-1转基因小鼠易患T细胞淋巴瘤，而E mu-myc转基因小鼠易患B细胞前淋巴瘤。在这里，我们显示双转基因E mu-myc E mu-pim-1小鼠在子宫内表现出前B细胞白血病。移植到受体小鼠中后，源自胚胎的双转基因白血病细胞经常发展为高度恶性的单克隆肿瘤，这表明在疾病发展过程中还发生了其他的（表观）遗传事件。

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《Molecular and Cellular Biology》 |1991年第2期|共4页
作者
S Verbeek; M van Lohuizen; M van der Valk; J Domen; G Kraal; A Berns;
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中图分类细胞生物学;
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2. Strain-dependency of chromosomal abnormalities in lymphomas developed in E mu-myc transgenic mice. [J] . Akagi K, Yamamura K Japanese Journal of Cancer Research . 2001,第5期

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3. Pre-B-cell leukemias in Btk|[sol]|Slp65-deficient mice arise independently of ongoing V(D)J recombination activity [J] . V B T Ta, A B de Haan, M J W de Bruijn, Leukemia . 2011,第1期

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6. Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. [O] . S Verbeek, M van Lohuizen, M van der Valk, 1991

机译：带有E mu-myc和E mu-pim-1转基因的小鼠在出生前会发展为B细胞白血病。
7. Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. [O] . Verbeek, S, van Lohuizen, M, van der Valk, M, 1991

机译：带有E mu-myc和E mu-pim-1转基因的小鼠在出生前会发展为B细胞白血病。
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机译：试图在体内使用锌来防止无肿瘤和携带L1210白血病的B6D2F（sub 1）小鼠中的氮芥毒性。

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.

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